Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1997-03-14
1999-11-30
Witz, Jean C.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
415 2, 415 21, A61K 3848
Patent
active
059938102
ABSTRACT:
The present invention relates to the use of collagenase and/or one more substances which stimulate the production of naturally occurring collagenase in the cervix to induce labor in a female mammal, and in particular a female human or to terminate pregnancy in such a female mammal. The substances which stimulate the production of naturally occurring collagenase include Interleukin 1 beta, Interleukin 2, Interleukin 6, Interleukin 8 and tumor necrosis factor.
REFERENCES:
patent: 3678158 (1972-07-01), Sussman
patent: 4174389 (1979-11-01), Cope
patent: 4338300 (1982-07-01), Gelbard
Coulam et al., Prostaglandins, Leukotrienes Essent. Fatty Acids 49(6): 959-961 (1993).
Gonzalez et al., Ginecologia Y Obstetricia De Mexico 62: 27-30 (Jan. 1994).
Ohno et al., European Journal of Endocrinology 130(5): 478-484 (May 1994).
Goshowaki et al., Protaglandins 36(1): 107-114 (1988).
Zicari et al., Journal of Reproductive Immunology 29: 197-208 (1995).
Chwalisz et al., Human Reproduction 9(11): 2173-7281 (1994). Abstract.
El Maradny et al., Eur. J. Obstet. Gynecol. Reprod. Biol. 60(1): 75-80 (1995). Abstract.
Ito et al., Biol. Reprod. 37(3): 511-517 (1987). Abstract.
Arck et al., American Journal of Reproductive Immunology 33(1): 74-80 (1995). Abstract.
Rajabi, M. R. et al "Elevated tissue levels of collangenase during dilation of uterine cervix in human parturation"; American Journal of Obstetrics and Gynecology, vol. 159, No. 4, pp. 971-976 (1988).
Osmers, R. et al "Collangenase activity in the cervix of non-pregnant and pregnant woman"; Archives of Gynecology and Obstetrics, vol. 248, No. 2, pp. 75-80 (1990).
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