Method of site-specific alteration of RNA and production of enco

Details Method of site-specific alteration of RNA and production of enco Method of site-specific alteration of RNA and production of enco

1992-02-19

1993-06-15

Wax, Robert A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 257, 536 221, 536 235, 935 2, 935 8, 935 36, C12N 1511, C07H 2104

Patent

active

052200078

ABSTRACT:
A method of site-directed alteration (removal or removal followed by replacement) of selected nucleotides in an RNA molecule, as well as to mixed phosphate backbone oligonucleotides useful in the method. It further relates to a method of producing polypeptides or proteins encoded by the RNA molecule altered by the present method. Through use of the present method, site-directed cleavage of an RNA molecule is effected, followed by excision of the selected or target segment of the RNA molecule.

REFERENCES:
patent: 5013830 (1991-05-01), Ohtsuka et al.
Walder, R. Y., et al., 1988, Proceedings of the National Academy of Sciences, USA, 85: 5011-5015.
Fardon, P. J., et al., 1989, Nucleic Acids Research 17(22): 9193-9204.
Quartin, R. S., et al., 1989, Nucleic Acids Research 17(18): 7253-7262.
Stein, L. A., et al., 1988, Nucleic Acids Research 16(8): 3209-3221.

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