Method of simultaneously enhancing analgesic potency and attenua

Details Method of simultaneously enhancing analgesic potency and attenua Method of simultaneously enhancing analgesic potency and attenua

1994-07-19

1996-04-30

Reamer, James H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514811, 514812, A61K 3114

Patent

active

055125786

ABSTRACT:
This invention relates to a method of selectively enhancing the analgesic potency of morphine and other clinically used bimodally-acting opioid agonists and simultaneously attenuating development of physical dependence, tolerance and other undesirable side effects caused by the chronic administration of said bimodally-acting opioid agonists comprising the co-administration of a bimodally-acting opioid agonist which activates both inhibitory and excitatory opioid receptor-mediated functions of neurons in the nociceptive (pain) pathways of the nervous system and an opioid receptor antagonist which selectively inactivates excitatory opioid receptor-mediated side effects. This invention also relates to a method of using excitatory opioid receptor antagonists alone to block the undesirable excitatory side effects of endogenous bimodally-acting opioid agonists which may be markedly elevated during chronic pain. This invention further relates to a method of long-term treatment of previously detoxified opiate, cocaine and alcohol addicts utilizing said excitatory opioid receptor antagonists, either alone or in combination with low-dose methadone, to prevent protracted physical dependence, and to compositions comprising an excitatory opioid receptor antagonist of the invention and a bimodally-acting opioid agonist.

REFERENCES:
patent: 4760069 (1988-07-01), Rezeszotarski et al.
patent: 4889860 (1989-12-01), Rezeszotarski et al.
patent: 5075341 (1991-12-01), Mendelson et al.
patent: 5317022 (1994-05-01), Borsodi et al.
patent: 5321012 (1994-06-01), Mayer et al.
patent: 5352680 (1994-10-01), Portoghese et al.

Affiliated with

Also associated with

Rating

Method of simultaneously enhancing analgesic potency and attenua does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of simultaneously enhancing analgesic potency and attenua, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of simultaneously enhancing analgesic potency and attenua will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-628983