Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals – Carrier is inorganic
Patent
1987-10-21
1989-05-23
Brown, Johnnie R.
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
Carrier is inorganic
4272556, 436828, 435 6, 435 7, 134 42, G01N 33552, C12Q 168, C23G 1600, B08B 700
Patent
active
048330930
ABSTRACT:
The present invention relates to a method of silanizing surfaces for use in detecting organic molecules and biomolecules by means of surface-sensitive detection methods. The molecules to be detected become covalently bonded to the solid, plane test surface which contains, by means of silanization, groups which are functional for the covalent bonding. The invention relates to a silanization technique, which combines a special cleaning technique for the surfaces to be silanized and a silanization process at a low pressure and with the silane in gas phase and at an enhanced temperature of the surfaces to be silanized. The method gives reproducible surfaces provided with stable, homogenous and functional silane layers of mono-layer character.
REFERENCES:
patent: 3276853 (1966-10-01), Eakins
patent: 3519538 (1970-07-01), Messing
patent: 3652761 (1972-03-01), Weetall
patent: 3831432 (1974-08-01), Cox
patent: 3924032 (1975-12-01), Hertl
patent: 4046870 (1977-09-01), Hertl et al.
Buzek et al, Stoichiometry and Kinetics of the Reaction of Silica with Organosilicon Compounds, Journal of Colloid and Interface Science, vol. 79, No. 1, Jan. 1981, pp. 47-55.
Hertl, Mechanism of Gaseous Siloxane Reaction with Silica I., The Journal of Physical Chemistry, vol. 72, No. 4, Apr. 1968, pp. 1248-1253.
Hertl, Mechanism of Gaseous Siloxane Reaction with Silica II., The Journal of Physical Chemistry, vol. 72, No. 12, Nov. 1968, pp. 3993-3997.
Methods in Enzymology (Klaus Mosbach, Ed.), vol. 44, 1976, Academic Press, pp. 134-149.
Sagiv, Organized Monolayers by Adsorption. 1. Formation and Structure of Oleophobic Mixed Monolayers on Solid Surfaces, Journal of the American Chemical Society, vol. 102, Jan. 2, 1980, pp. 92-98.
Handbook of Thin Film Technology (Leon I. Maissel & Reinhard Glang, Eds.), 1970, McGraw-Hill Book Company, pp. 6-37 to 6-42.
Janata et al., Chemically Sensitive Field Effect Transistors, Ion-Selective Electrodes in Analytical Chemistry (H. Freiser, Ed.), vol. 2, 1980, pp. 107-172.
Bascom, Structure of Silane Adhesion Promoter Films on Glass and Metal Surfaces, Macromolecules, vol. 5, No. 6, Nov.-Dec. 1972, pp. 792-798.
Mittal et al., Vapor Deposited Silanes and Other Coupling Agents, J. Adhesion, 1976, vol. 8, pp. 93-97.
Haller, Covalently Attached Organic Monolayers on Semiconductor Surfaces, Journal of the American Chemical Society, vol. 100, Dec. 20, 1978, pp. 8050-8055.
Carlsson et al., Protein Thiolation and Reversible Protein-Protein Conjugation, Biochem. J. (1978), vol. 173, pp.723-737.
Tadros et al, Adsorption of Potential-Determining Ions at the Silica Aqueous Electrolyte Interface and the Role of Somecations, J. Electronal. Chem., vol. 17 (1978), pp. 267-275.
Chemical Abstracts, vol. 92 (1980), abstract No. 90 298e, Biophys.-Struct. Mech. 1979, 6(1) 67-80 (Eng.).
Chemical Abstracts, vol. 93 (1980), abstract No. 91 093s, J. Appl. Biochem. 1979, 1(5-6), 442-7 (Eng.).
Chemical Abstracts, vol. 91 (1979), abstract No. 188 710n, Sb. Nauchn. Tr., Vses. Nauchno-Issled. Inst. Lyuminoforov Osobo Chist. Veshchestv. 1978, 17, 90-4 (Russ.).
Malmqvist Magnus
Olofsson Goran
Brown Johnnie R.
Forsvarets Forskningsanstalt
Jay Jeremy M.
LandOfFree
Method of silanization of surfaces does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of silanization of surfaces, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of silanization of surfaces will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1730701