Method of sequencing peptides and proteins using a valve block a

Details Method of sequencing peptides and proteins using a valve block a Method of sequencing peptides and proteins using a valve block a

1989-08-22

1992-01-21

Hill, Jr., Robert J.

Chemistry: analytical and immunological testing

Peptide, protein or amino acid

Amino acid or sequencing procedure

422103, 422116, 530345, 530402, G01N 3368

Patent

active

050827880

ABSTRACT:
A method is provided for sequencing peptides and proteins in which the coupling and cleavage reagents are supplied through a valve block assembly with internal delivery channels and a common outlet channel. The outlet channel communicates with a reaction chamber in which the sample is placed. Access of reactants to the delivery channels is controlled by diaphragm valves, preferably equipped with relief grooves to accommodate deformation of the diaphragm. Reservoirs feeding the delivery channels have an inert atmosphere controlled by pressurizing and venting channels in the valve block. Exposure of plastic tubing to oxygen is kept to a minimum. Reactants are thereby supplied without significant cross-contamination or oxidative decomposition.

REFERENCES:
patent: 3725010 (1973-04-01), Penhasi
patent: 3829531 (1975-07-01), Gilbert
patent: 4065412 (1977-12-01), Dreyer
patent: 4704256 (1987-11-01), Hood et al.
Edman et al., European J. Bi. Chem., vol. 1, pp. 80-91, 1967.

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