Method of separating alpha-L-aspartyl-L-phenylalanine methyl est

Details Method of separating alpha-L-aspartyl-L-phenylalanine methyl est Method of separating alpha-L-aspartyl-L-phenylalanine methyl est

1989-04-25

1991-02-19

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

560 40, 560 41, C07C10352

Patent

active

049946056

ABSTRACT:
A method for crystallizing alpha-L-aspartyl-L-phenylalanine methyl ester (APM) is disclosed. The APM is crystallized from a C.sub.1 -C.sub.3 -alcohol/water solution (30-80:70-20 (v/v)). The ester crystallized by (i) concentrating the solution, (ii) cooling the solution, (iii) adjusting the water:alcohol ratio, or (iv) a combination thereof.

REFERENCES:
patent: 3901871 (1975-08-01), Anderson
patent: 4394308 (1983-07-01), Sampathkumar et al.
Vogel et al., A Textbook of Practical Organic Chemistry, 3rd ed. Longmans, Green and Co., N.Y. 1956, pp. 122-131.
The Merck Index, 9th ed. Merck and Co. Inc., Rahway, N.J., U.S.A., 1976, Entry No. 7644, p. 1017.

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