Method of selectively sulfating peptides

Details Method of selectively sulfating peptides Method of selectively sulfating peptides

1989-03-30

1991-10-22

Doll, John

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

530336, 530345, 530324, 530338, A61K 3702, C07K 100

Patent

active

050596799

ABSTRACT:
The invention provides a method and reagent for the modification of polypeptides useful in experimental research in the area of genetic engineering starting from a polypeptide such as hCCK-33 in an unsulfated form which contains Tyr and Ser and/or Thr residues by first protecting the amino-groups in the starting polypeptide, masking the OH-groups in the Ser and/or Thr residues and selectively sulfating the OH-groups in the Tyr residues after deprotection.

REFERENCES:
Kurano et al., J. Chem. Soc. Chem. Commun. (1987) 323-325.

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