Method of selectively removing lipoprotein from blood plasma or

Details Method of selectively removing lipoprotein from blood plasma or Method of selectively removing lipoprotein from blood plasma or

1977-03-01

1978-06-20

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424101, 424177, 23230B, C07G 700

Patent

active

040961362

ABSTRACT:
The invention relates to the use of a sulphated ion exchanger to selectively remove lipoproteins from blood plasma or serum. Although the attraction between sulphate groups and proteins has long been recognized it has now unexpectedly been found that cationic ion exchangers whose ion exchange capacity is provided by sulphate groups bind lipoproteins selectively in presence of other plasma or serum proteins and ions when they are equilibrated with solutions containing divalent cations and the same cation is added to the plasma or serum. Types of ion exchanger matrices and applications of the utlity are discussed.

REFERENCES:
patent: 3562289 (1971-02-01), Battista et al.
patent: 3573277 (1971-03-01), Grant
patent: 3838143 (1974-09-01), Grant
patent: 3842061 (1974-10-01), Andersson et al.
patent: 3920625 (1975-11-01), Andersson et al.
Methods in Enzymology, vol. XXII, Jakoby, 1971, pp. 273-285.
Introduction to Modern Biochemistry, 3rd Edition, Karlson, 1968, pp. 395-396.
Chem. Abstracts, vol. 71, 1969, 114440q, Sjovall et al.

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