Method of selectively inhibiting prostaglandin G/H synthase-2

Details Method of selectively inhibiting prostaglandin G/H synthase-2 Method of selectively inhibiting prostaglandin G/H synthase-2

1995-03-31

1996-11-05

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514335, 514444, 514471, 514472, 514473, 514461, 514532, 514538, 514539, 514530, 514455, 514437, A61K 3144, A61K 3138, A61K 3134, A61K 31235, A61K 3124, A61K 31215, A61K 3135

Patent

active

055718256

ABSTRACT:
The present invention provides a method of selectively inhibiting prostaglandin G/H synthase-2 that comprises administering to a patient in need of such inhibition an inhibiting amount of a compound having the Formula I, II or III ##STR1## wherein the R groups and heterocycles are defined in the disclosure.

REFERENCES:
patent: 3558640 (1971-01-01), Shen et al.
patent: 4066686 (1978-01-01), Lafon
patent: 4205087 (1980-05-01), Waring
patent: 4489095 (1984-12-01), Lafon
patent: 4964893 (1990-10-01), Brannigan et al.
patent: 5366982 (1994-11-01), Dereu et al.
Remingtons Pharmaceutical Sciences, 16th Ed., 1980, p. 431.

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