Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1988-04-08
1989-09-26
Kight, John
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
514 8, 514885, A61K 3702, A61K 3578, A61K 3580, C07G 700
Patent
active
048699039
ABSTRACT:
A method of inhibiting HIV replication in and cellular proliferation of HIV-infected cells. The infected cells are exposed to a single-chain ribosome inactivating protein, at a protein concentration and for an exposure period sufficient to produce a substantial reduction in (a) the level of HIV antigen or reverse transcriptase associated with the infected cells, (b) the ratio of viability of infected/uninfected T cells, and/or (c) the ratio of HIV antigen/cellular antigen in infected macrophages. The method is used to treat HIV infection in humans.
REFERENCES:
patent: 3104204 (1963-09-01), Olson
patent: 3104208 (1963-09-01), Olson et al.
patent: 3230153 (1966-01-01), Olson et al.
patent: 3842062 (1974-10-01), Eastman
Armstrong, W. H., Presented at the International Conference on Aids, Jun. 23-25, 1986, Paris.
Barbieri, L. et al, Biochem J. 182:633 (1979).
Barbieri, L. et al, Biochem J. 186:443 (1980).
Barbieri, L. et al, Biochem J. 203:55 (1982).
Barnes, D. M., Science, 235:964 (1987).
Broder et al, Lancet ii:627 (1985).
Broder et al, Nature 325-:773 (1987).
Chan, W. Y. et al, Contraception, 29:91 (1984).
Chayt, K. J. et al, JAMA, 256:2356 (1986).
Coffin, J. et al, Science, 232:697 (1986).
Crowe, S., Mills, J., and McGrath, M. S., submitted for publication.
Curran, J. W. et al, Science, 229:1352 (1985).
Dalgliesh, A. G. et al, Nature, 312:763 (1984).
Fahey, J. L., Am J Me7, 76:95 (1984).
Falasca, A. et al, Biochem J, 207:505 (1982).
Foa-Tomasi, L. et al., Arch Virol, 71:323 (1982).
Foung, S. K, H. et al., Human Hybridomas and Monoclonal.
Antibodies, E. G. Engleman et al., eds, Plenum Press, N.Y., p. 437 (1985).
Gartner S., Science, 233:215 (1986a).
Gartner S. et al., JAMA, 256, 2365 (1986b).
Gaspani-Compani, A., Biochem J., 186:439 (1980).
Gu, Zi-wei et al., Acta Chemica Sinica, 43:943 (1984).
Ho, D. D. et al., J Clin Invest, 77:1712 (1986).
Hsu, K. J. et al., Acta Zool Sin, 22:149 (1976).
Hoffman, A. E. et al., Virology, 147:326 (1985).
Hwang, Y. N., Chinese J Integrated Trad and Western Medicine, 7:154 (1987).
Irvin, J. D., Pharmacol Ther, 21:371 (1983).
Jilka, C. et al., Cancer Res., 43:5151 (1983).
Kao, H. et al., Acta Biol Exp Sin, 11:253 (1978).
Kennedy, R. C. et al., Science, 231:1556 (1986).
Kezhan, Pan et al., Supplement of Proc of China-Japan Bilateral Symposium on Biophys, Wuxi, China (May 1985).
Klatzmann, D. et al., Science, 225:59 (1984a).
Klatzmann, D. et al., Nature, 312:767 (1984b).
Koenig, S. et al., Science, 233:1089 (1986).
Kubota, S. et al., Biochim Biophys Acta, 871:101 (1986).
Kuo-Fen, C. et al., Obs and Gyn, 59(4):494 (1982).
Law, L. K. et al., J Reprod Fert, 69:597 (1983).
Licastro, F. et al., Virchows Arch B Cell Path, 33:257 (1980).
Lifson, J. D. et al., Science, 232:1123 (1986a).
Lifson, J. D. et al., Nature, 323:725 (1986b).
Lifson, J. D. et al., J. Exp Med, 164:2101 (1986c).
Lifson, J. D., J Exp Med, 164:2101 (1986c).
Lin, J. Y. et al., Cancer Res, 30:2431 (1970).
Lin, J. Y. et al., Toxicon, 16:653 (1978).
Maddon, J. P., Cell, 47:333 (1986).
McCormick, J. B. et al., Lancet, ii:1367 (1984).
McDougal, J. S., Science, 231:382 (1985a).
McDougal, J. S. et al., J Immunol, 135:3151 (1985b).
McDougal, J. S. et al., J Immunol, 137:2937 (1986).
Olnes, S. et al., in Molecular Action of Toxins and Viruses, 51-105 Elsevier, Amsterdam (1982).
Popovic, M. et al., Science, 224:497 (1984).
Roberts, W. K., Biochemistry, 18:2615 (1979).
Salvedt, E., Biochim, Biophys Acta, 451:536 (1976).
Sodroski, J. et al., Nature, 322:470 (1986).
Spreafico, F. et al., Int. J. Immunopharmac, 5(4):335 (1983).
Stanley, W. S. et al., Proc Nat Acad Sci, U.S.A., 76:303 (1979).
Steicher, H. Z. et al., JAMA, 256:2390 (1986).
Stirpe, F. et al., J Biol Chem, 255:6947 (1980).
Stirpe, F. et al., Biochem J. 195:399 (1981).
Takemoto, D. J. et al., Prep Biochem, 12(4):355 (1982).
Takemoto, D. J. et al., Prep Biochem, 13(4):371 (1983a).
Takemoto, D. J. et al., Prep Biochem, 13(5):397 (1983b).
Wang, Yu et al., Int Symposium on Org Chem of Medicinal Natural Products, Shanghai, China (Nov., 1985).
Xiong, Y. Z. et al., Acta Zool Sin, 11:236 (1976).
Xuejan, Z. et al., Nature, 321:477 (1986).
Yarochan, R. et al., Lancet, i:575 (1986).
Yarochan, R. et al., Lancet, i:132 (1987).
Yeung, H. W. et al., in Adv in Chinese Medicinal Materials Res, edited by H. M. Change et al., World Scientific Pub, Singapore p. 311 (1985).
Res, edited by H. M. Change et al., World Scientific Pub, Singapore p. 311 (1985).
Yeung, H. W. et al., Int J. Peptide Protein Res, 27:325 (1986).
Fernandez-Puentes et al., Cell, vol. 20, 769-775, Jul. (1980), Viral Infection Permeabilizes Mammalian Cells to Protein Toxins.
Fernandez-Puentes, Mollecular and Cellular Biochemistry 50, 185-191 (1983), Permeability to alpha sarcin in virus-infected cells.
Calderwood, S. B. et al., Proc Natl Acad Sci U.S.A., 84:4364-4368 (Jul. 1987).
Conde, F. P., FEMS Microbiology Letters 4:349-55 (1978) et al.
Coleman, W. H., Biochemuta et Biophysica Aca, 696:239-244 (1982) et al.
Endo, Y., J of Biol Chem. vol. 267 No. 15 9054-9060 (1982) et al.
Endo, Y., J of Biol Chem, vol. 262 No. 12 5908-5912 (1987) et al.
Fernandez-Luna, J. L. Biochemistry 24:861-867 (1985) et al.
Fernandez-Puentes, C., Cell 20:769-775 (Jul. 1989) et al.
Fernandez-Puentes, C., Mol Cell Biochem 50:185 (1983).
Foa-Tomasi, L., Archives of Virology 71:323-332 (1982) et al.
Gasperi-Campani, A., FEBS Letters 76:2:173-176 (1977) et al.
Grasso, S., Phytophathology 68:199-205 (1978) et al.
Irvin, J. D. et al., Archives of Biochemistry and Biophysics, vol. 200 No. 2, 418-425 (4/1/80).
Irvin, J. D., Archives of Biochemistry and Biophysics 169:522-528 (1975).
Lopez-Otin, C. et al., Eur J Biochem 143:621-634 (1984).
Maraganore, J. M., J of Biological Chem, 262:24:11628-11633 (1987) et al.
Olsnes, S., Molecular Action of Toxins and Viruses, et al.
Elsevier Biomedical Press (1982).
Olsnes, S., Nature, 328:474-475 (Aug. 1987).
Olson, B. H., Applied Microbiology, 13:3:322-326 (May 1965), et al.
Olson, B. H. et al., Applied Microbiology 13:3:314-321 (May 1985).
Ragetli, H. W. J. et al., Virology 18:232:240 (1962).
Rodriquez, R. et al., Biochemical and Biophysical Research Communications, 108:1:315-321 (9/16/82).
Sacco, G. et al., J of Biol Chem, 258:9:5811-5818 (1983).
Sarngadharan, M. G. et al., Fundamental Virology, Chapt. 32, pp. 681-707.
Sargiacomo, M. et al., FEBS 0154 157:1:150-154 (1983).
Schindler, D. G., Nucleic Acids Research, vol. 4 No. 4 (Apr. 1977).
Stevens, W. A. et al., Experientia 37 (1981).
Takemoto, D. J. et al., Biochemical and Biophysical Research Communications, vol. 94 No. 1 (5/14/80).
Xuejun Z. et al., Nature, 321:477-478 (May 1986).
Yeung, H. W. et al., Advances in Chinese Medicinal Materials Research, 311-318 (1985).
Kronke, M. et al., Blood, 65:6:1416-1421 (1985).
Kronke, M. et al., Cancer Research, 46:3295-3298 (Jul. 1986).
Hwang Kuo
Lifson Jeffrey D.
McGrath Michael S.
Yeung Hin-Wing
Dehlinger Peter J.
Genelabs Incorporated
Kight John
Nutter Nathan M.
LandOfFree
Method of selectively inhibiting HIV does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of selectively inhibiting HIV, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of selectively inhibiting HIV will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-186460