Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving glucose or galactose
Reexamination Certificate
2007-06-26
2007-06-26
Gitomer, Ralph (Department: 1657)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving glucose or galactose
C435S025000, C436S067000
Reexamination Certificate
active
10332790
ABSTRACT:
A method of determining glycated hemoglobin is provided, by which a ratio of the glycated hemoglobin in a sample can be determined accurately and easily. The ratio of glycated hemoglobin can be determined by degrading a glycated hemoglobin in a whole blood sample selectively with a protease to give a glycated hemoglobin degradation product; causing a redox reaction between a glycation site of the glycated hemoglobin degradation product and a fructosyl amino acid oxidoreductase; and determining this redox reaction. Further, as shown in FIG.1, in a whole blood sample, there is a correlation between the ratio of the glycated hemoglobin determined by this method and an HbA1c concentration. Thus, without determining the glycated α-amino group as a characteristic structure of HbA1c, an amount of HbA1c can be determined accurately and easily from the determined ratio of the glycated hemoglobin.
REFERENCES:
patent: 5370990 (1994-12-01), Staniford et al.
patent: 5387109 (1995-02-01), Ishikawa et al.
patent: 5631140 (1997-05-01), Kobold et al.
patent: 5712138 (1998-01-01), Kato et al.
patent: 6352835 (2002-03-01), Komori et al.
patent: 6790665 (2004-09-01), Yonehara et al.
patent: 6825016 (2004-11-01), Ishimaru et al.
patent: 7070948 (2006-07-01), Sakaue et al.
patent: 2002/0025546 (2002-02-01), Komori et al.
patent: 2004/0247587 (2004-12-01), Ishimaru et al.
patent: 1 002 874 (2000-05-01), None
patent: 1 223 224 (2002-07-01), None
patent: 2-195900 (1990-08-01), None
patent: 2000-300294 (2000-10-01), None
patent: 2001-54398 (2001-02-01), None
patent: 2001-204495 (2001-07-01), None
patent: 97/13872 (1997-04-01), None
patent: WO 97/13872 (1997-04-01), None
patent: WO 98/48043 (1998-10-01), None
patent: 01/25475 (2001-04-01), None
Gil H, Mata-Segreda J, Schowen R. Acta Cient. Venez. (1997) 42, 16-23 Effect of non-enzymqatic glycosylation on reactivity in proteolysis. Article in Spanish.
EPO Search Report for PCT/JP01/06064 Provided by Applicant.
Sakurabayashi, et al., “New Enzymatic Assay for Glycohemoglobin”, Clinical Chemistry, American Association for Clinical Chemistry, Washington. DC 49:2, 269-274 (2003).
ARKRAY, Inc.
Gitomer Ralph
Hamre Schumann Mueller & Larson P.C.
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