Method of selectively assaying adiponectin multimers

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S007100, C436S501000, C436S506000, C436S518000, C424S130100, C424S178100, C530S300000, C530S350000

Reexamination Certificate

active

08039223

ABSTRACT:
Kits and methods for selectively assaying a target adiponectin multimer in a biological sample. Such methods accurately evaluate the relationship between a disease and adiponectin through selective assay of adiponectin multimers and provide information that cannot be obtained through measurement of the total amount of adiponectin alone. A method for selectively assaying a target adiponectin multimer in a biological sample comprising distinguishing target adiponectin multimer from the other adiponectin multimers by using a protease and/or an antibody.

REFERENCES:
patent: 4444879 (1984-04-01), Foster et al.
patent: 2000-304748 (2000-11-01), None
patent: 2002-363094 (2002-12-01), None
patent: 03/016906 (2003-02-01), None
Waki et al. (The Journal of Biological Chemistry, vol. 278, No. 41, Oct. 10, 2003, pp. 40352-40363).
Kondo et al. (Diabetes, Jul. 2002, vol. 51, No. 7, pp. 2325-2328).
Waki, Hironori et al., “Impaired Multimerization of Human Adiponectin Mutants Associated with Diabetes”, The Journal of Biological Chemistry, vol. 278, No. 41, pp. 40352-40363, 2003.
Pajvani, Utpal B. et al., “Complex Distribution, Not absolute amount of Adiponectin, Correlates with Thiazolidinedione-mediated Improvement in Insulin Sensitivity”, The Journal of Biological Chemistry, vol. 279, No. 13, pp. 12152-12162, 2004.
Akamatsu, Yu “Development of “human adiponectin ELISA kit” and analysis for molecular form of serum adiponectin”, Medical Science Digest, vol. 28, No. 12, pp. 502-505, 2002. ( with Partial English translation).
Yamauchi, T. et al., “The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity”, Nature Medicine, vol. 7 No. 8, pp. 941-946, 2001.
Nakano, Yasuko et al., “Isolation and Characterization of GBP28, a Novel Gelatin-Binding Protein Purified from Human Plasma”, J. Biochem., vol. 120, No. 4, pp. 803-812, 1996.
Tsao, Tsu-Shuen et al., “Oligomerization State-dependent Activation of NF-κB Signaling Pathway by Adipocyte Complement-related Protein of 30 κDa (Acrp30)”, The Journal of Biological Chemistry, vol. 277, No. 33, pp. 29359-29362, 2002.
Pajvani, Utpal B. et al, “Structure-Function Studies of the Adipocyte-secreted Hormone Acrp30/Adiponectin”, The Journal of Biological Chemistry, vol. 278, No. 11, pp. 9073-9085, 2003.
Yamamoto, Yukihiro et al, “Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-cholesterol, independent of body mass index, in the Japanese population”, Clinical Science, vol. 103, pp. 137-142, 2002.
Tsao Tsu-Shuen, et al., “Role of Disulfide Bonds in Acrp30/Adiponectin Structure and Signaling Specificity”, The Journal of Biological Chemistry by the American Society for Biochemistry and Molecular Biology, Inc. vol. 278, No. 50, Sep. 30, 2003, pp. 50810. XP-002408188.
Yukio Arita, et al. “Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity”, Biochemical and Biophysical Research Communications, XP-000867719, vol. 257, No. 1, Apr. 2, 1999, pp. 79-83.
Waki, et al. (The Journal of Biological Chemistry, vol. 278, No. 41, Oct. 10, 2003, pp. 40352-40363.

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