Surgery: light – thermal – and electrical application – Light – thermal – and electrical application – Electrical therapeutic systems
Patent
1998-11-09
2000-05-30
Kamm, William E.
Surgery: light, thermal, and electrical application
Light, thermal, and electrical application
Electrical therapeutic systems
A61N 104
Patent
active
060686502
ABSTRACT:
A method and apparatus for in vivo electroporation therapy. Using electroporation therapy (EPT) as described, tumors treated by a combination of electroporation using the apparatus and a chemotherapeutic agent caused regression of tumors in vivo. In one embodiment, a method of EPT utilizes low voltage and long pulse length for inducing cell death. One embodiment includes a system for clinical electroporation that includes a needle array electrode having a "keying" element that determines the set point of the therapy voltage pulse and/or selectable array switching patterns. A number of electrode applicator designs permit access to and treatment of a variety of tissue sites. Another embodiment provides a laparoscopic needle applicator that is preferably combined with an endoscope for minimally invasive EPT.
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Dev Sukhendu B.
Dimmer Steven C.
Hofmann Gunter A.
Levatter Jeffrey I.
Nanda Gurvinder S.
Gentronics Inc.
Haile Lisa A.
Kamm William E.
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