Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1984-09-27
1989-06-27
Wiseman, T. G.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
435 68, 4352523, 435320, 435872, 435886, 435889, 435896, 43525235, C12N 1500, C12N 120, C12P 2100
Patent
active
048430021
ABSTRACT:
A novel method of selecting Streptomyces recombinant DNA-containing host cells and vectors useful in exemplifying the method are described. The vectors confer apramycin resistance to sensitive Streptomyces host cells and thus provide a convenient method of selecting Streptomyces transformants. The apramycin resistance-conferring gene used in the method is an acetyltransferase aac(3)IV gene and can be isolated from E. coli K12 BE1041/pKC309 (NRRL B-15827) on an .about.1.5 kb PstI-EcoRI restriction fragment.
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Rao R. Nagaraja
Stanzak Richard K.
Dahling Gerald V.
Eli Lilly and Company
Mays Thomas D.
Whitaker Leroy
Wiseman T. G.
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