Method of selecting a compound for producing analgesia

Details Method of selecting a compound for producing analgesia Method of selecting a compound for producing analgesia

1999-04-23

2000-07-11

Davenport, Avis M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

435 71, 435 78, 435 39, 514 12, 530324, C12Q 100, G01N 3353, A61K 3800

Patent

active

060870915

ABSTRACT:
A method of producing analgesia in nociceptive and neuropathic pain is disclosed. The method includes administering to a subject an omega conopeptide which is characterized by its ability to (a) inhibit electrically stimulated contraction of the guinea pig ileum, and (b) bind selectively to omega conopeptide MVIIA binding sites present in neuronal tissue. Also disclosed are novel omega conotoxin peptides effective in producing analgesia.

REFERENCES:
patent: 4975446 (1990-12-01), Trager et al.
patent: 5189020 (1993-02-01), Miljanich et al.
patent: 5587454 (1996-12-01), Justice et al.
patent: 5824645 (1998-10-01), Justice et al.
patent: 5859186 (1999-01-01), Justice et al.
Andersson, S.E. and Le Greves, P., "Ruthenium Red and Capsaicin Induce a Neurogenic Inflammatory Response in the Rabbit Eye: Effects of .omega.-conotoxin GVIA and tetrodotoxin,"Eur. J. Pharmacol., 209:176-183 (1991).

Affiliated with

Also associated with

Rating

Method of selecting a compound for producing analgesia does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of selecting a compound for producing analgesia, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of selecting a compound for producing analgesia will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-540686