Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined...
Reexamination Certificate
2011-08-16
2011-08-16
Weber, Jon P (Department: 1657)
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
Reexamination Certificate
active
07998508
ABSTRACT:
The present invention relates to a method of screening placental proteins responsible for pathophysiology of preeclampsia, and a marker for early diagnosis and prediction of preeclampsia. In accordance with one aspect of the present invention, there is provided a method of screening placental proteins responsible for pathophysiology of preeclampsia by 2D E-proteomics analysis, comprising: isolating placental proteins from a placental tissue; separating the isolated proteins two-dimensionally through 2D electrophoresis; and comparing and analyzing the separated proteins based on scanned gel images and differences in the images between normal placental proteins and preeclamptic placental proteins, wherein the comparison and analysis of the placental proteins based on the scanned gel images and differences in the images are accomplished by selecting proteins with differences of 140% or more between two placentas.
REFERENCES:
Mine et al. “Proteome analysis of human placetae: pre-eclampsia versus normal pregnancy”, Placenta, 2007, 28:676-687.
Shankar et al. “An emerging role for comprehensive proteome analysis in human pregnancy research”, Reproduction, 2005, 129:685-696.
Han Jin
Kim Na Ri
Park Won Sun
Inje University Industry-Academic Cooperation Foundation
Mannava & Kang, PC
Park Hyunho
Shen Bin
Weber Jon P
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