Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2003-05-28
2009-06-02
Wessendorf, T. D. (Department: 1639)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007100, C435S091500, C424S009100, C424S009340, C424S009341, C514S002600, C514S018700
Reexamination Certificate
active
07541157
ABSTRACT:
The invention relates to an amplification-free method of screening groups of radioactive molecules, comprising at least the following steps: (1) the group of molecules is administered to at least one animal; (2) at least one of the animals is slaughtered and the tissue distribution of the radioactivity of the molecules administered is analyzed in vivo; (3) sections of tissue or organs in which a radioactivity signal is detected are selected; (4) radioactive fractions from the sections of tissue or organs are isolated using suitable techniques such as chromatography and/or extraction techniques; and (5) the molecule(s) from the radioactive fractions obtained in step 4 are characterized using suitable analysis techniques such as chromatography and/or mass spectrometry.
REFERENCES:
patent: 5753206 (1998-05-01), McBride et al.
patent: 6306365 (2001-10-01), Ruoslahti et al.
patent: 6403770 (2002-06-01), Yu et al.
patent: 01/20331 (2001-03-01), None
Jiracek J. et al: “Development of the First Potent and Selective Inhibitor of the Zincendopeptidase Neurolysin Using a Systematic Approach Based on Combinatorial Chemistry of Phosphinic Peptides” Journal of Biological Chemistry, American Society Biological Chemists, vol. 271, No. 32, pp. 19606-19611, Aug. 9, 1996.
Dive Vincent et al: “RXP 407, a phosphinic peptide, is a potent inhibitor of angiotensin I converting enzyme able to differentiate between its two active sites” Proceedings of the National Academy of Sciences of the United States, vol. 96, No. 8, pp. 4330-4335, Apr. 13, 1999.
Buchardt J. et al: “Solid phase combinatorial library of phosphinic peptides for discovery of matrix metalloproteinase inhibitors” Journal of Combinatorial Chemistry, American Chemical Society, vol. 2, pp. 624-638, Sep. 13, 2000.
Beau Fabrice
Cotton Joël
Czarny Bertrand
Dive Vincent
Menez Andre
Commissariat a l''Energie Atomique
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
Wessendorf T. D.
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