Method of screening for the presence of a genetic defect...

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical

Reexamination Certificate

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C435S006120

Reexamination Certificate

active

08067209

ABSTRACT:
The present invention relates to a method for screening an individual for the presence in his/her genome of a genetic marker that is indicative of an increased risk of deep venous thrombosis, wherein the genetic marker is haplotype 2 of the fibrinogen γ gene (FGG-H2) as given in FIG.5A. The genetic marker comprises a set of one, two, three or four mutations in the nucleic acid material encoding fibrinogen γ, the mutations being selected from the group consisting of 129A/T (rs2066854), 7874G/A (rs20668β1), 9615′C/T (rs2066864) and 10034C/T (rs2066865).

REFERENCES:
patent: WO 2005/071114 (2005-08-01), None
International Search Report and Written Opinion for PCT/EP2006/003195; Oct. 20, 2006.
International Preliminary Report on Patentability; Oct. 3, 2007.
Bozic et al. “Fibrinogen PolymorphismsTaql,HaeIII andBc/I Are Not Associated with a Higher Risk of Deep Vein Thrombosis”Pathophysiology of Haemostasis and Thrombosis 33:164-169 (2003).
Database REFSNP ncbi, retrieved from NCBI Database accession No. RS2066854 (2004).
Database REFSNP ncbi, retrieved from NCBI Database accession No. rs2066864 (2001).
Database REFSNP ncbi, retrieved from NCBI Database accession No. rs2066865 (2003).
Database REFSNP ncbi, retrieved from NCBI Database accession No. rs2066861 (2004).
de Willige et al. “Genetic variation in the fibrinogen gamma gene increases the risk for deep venous thrombosis by reducing plasma fibrinogen γ1levels”Blood 106(13):4176-4183 (2005).
Drouet et al. “Plasma γ1/ γ1fibrogen ratio, a marker of arterial thrombotic activity: a new potential cardiovascular risk factor?”Blood Coagulation and Fibronolysis 10(suppl 1):S35-S39 (1999).
Fellowes et al. “Identification and Characterization of Five New Fibrinogen Gene Polymorphisms”Annals New York Academy of Sciences 936:636-541 (2001).
Manila et al. “Contribution of haplotypes across the fibrinogen gene cluster to variation in risk of myocardial infarction”Thromb. Haemost. 93:5470-577 (2005).

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