Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-05-08
2007-05-08
Mertz, Prema (Department: 1646)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007210, C435S007240
Reexamination Certificate
active
10333958
ABSTRACT:
The invention provides a method of screening for substances preventing or treating diseases in association with IL-6 family cytokine receptor malfunction, which comprises using a transgenic mouse or a part thereof expressing a gp130 variant, wherein said gp130 variant comprises a substitution or a deletion of a tyrosine residue, which corresponds to the tyrosine residue at position 759 of human gp130 protein, or a substitution, an insertion or a deletion of one or more amino acid residues in a region comprising said tyrosine residue.
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K. Ishihara et al., “The point mutation of tyrosine 759 of the IL-6 family cytokine receptor gp130 synergizes with HTLV-1 pX in promoting rheumatoid arthritis-like arthritis”, International Immunology, vol. 16., No. 3, pp. 455-465, Mar. 2004.
Hibi Masahiko
Hirano Toshio
Ishihara Katsuhiko
Hirano Toshio
Mertz Prema
Saten Pharmaceutical Co., Ltd.
Wenderoth , Lind & Ponack, L.L.P.
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