Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-04-06
1998-05-05
Hutzell, Paula K.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 2, 4352402, 436503, 436518, 436 72, G01N 33567
Patent
active
057472700
ABSTRACT:
An in vitro method for diagnosing hypersensitivity to silicon(e) antigen in subjects not previously exposed to silicon(e). The method involves obtaining a subset of lymphocytes from non-sensitized subjects and contacting the lymphocytes with silicon(e) for a sufficient period of time to cause sensitizing and proliferative responses.
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Stejskal et al, 1990. Lymphocyte transformation test for diagnosis of isothiazolinone allergy in man. J. Invest Dermatol 94:798-802.
Stejskal et al, 1986. The lymphocyte transformation test for diagnosis of drug-induced occupational allergy. J. Allergy Clin Immunol 77:411-426.
Shelton et al, 1985. Delayed hypersensitivity reaction to silicone breast implants. Annals of Allergy 54: 361. Abstract #96.
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Moseley et al., 1988. Divergent effects of silica on lymphocyte proliferation and immunoglobulin production. J. Appl. Physiol. 65: 350-357.
Ojo-Amaize et al., 1994. Silicone-specific blood lymphocyte response in women with silicone breast implants. Clinical and Diagnostic Laboratory Immunology 1: 689-695.
Van Voorhis et al., 1983. Relative efficacy of human monocytes and dendritic cells as accessory cells for T cell replication. J. Exp. Med. 158: 174-191.
Brotman Harris F.
Grun James L.
Hutzell Paula K.
Specialty Laboratories, Inc.
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