Method of screening for protein inhibitors and activators

Details Method of screening for protein inhibitors and activators Method of screening for protein inhibitors and activators

1989-08-10

1993-11-30

Rosen, Sam

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

4352401, 4352402, C12Q 102

Patent

active

052664643

ABSTRACT:
Inhibitors and activators of a protein whose expression affects a phenotypic characteristic of the cell, especially a cultural or morphological characteristic, are identified by their more pronounced effect on cells producing higher, usually non-naturally occurring, levels of the protein, than on cells producing little or none of the protein. In a preferred assay, the effect is observable with the naked eye.
By this method, tamoxifen is identified as an inhibitor of PKC activity in cell culture.

REFERENCES:
patent: 4480038 (1984-10-01), Cheng
patent: 4532204 (1985-07-01), Crespi et al.

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