Method of screening for protein inhibitors and activators

Details Method of screening for protein inhibitors and activators Method of screening for protein inhibitors and activators

1988-02-10

1990-12-25

Rosen, Sam

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

4352401, 4352402, C12Q 102

Patent

active

049802810

ABSTRACT:
Inhibitors and activators of a protein whose expression affects a phenotypic characteristic of the cell, especially a cultural or morphological characteristic, are identified by their more pronounced effect on cells producing higher, usually non-naturally occurring, levels of the protein, than on cells producing little or none of the protein. In a preferred assay, the effect is observable with the naked eye.
By this method, tamoxifen is identified as an inhibitor of PKC activity in cell culture.

REFERENCES:
patent: 4480038 (1984-10-01), Cheng
patent: 4532204 (1985-07-01), Crespi
Housey et al., Cell, vol. 52, 343-354, Feb. 12, 1988.
Julius, et al., Ectopic Expression of The Serotonin 1c Receptor and the Triggering of Malignant Transformation (1989) Science, vol. 244, pp. 1057-1062.

Affiliated with

Also associated with

Rating

Method of screening for protein inhibitors and activators does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of screening for protein inhibitors and activators, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of screening for protein inhibitors and activators will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1162293