Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1995-06-07
1999-03-02
Degen, Nancy
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
435 74, 435 771, 435 29, 435 691, C12N 121, C12N 100, C12P 2102, G01N 33573
Patent
active
058770070
ABSTRACT:
Cells useful in the pharmacological characterization of inhibitors or activators of proteins are provided. These cells a protein, the presence of which affects a particular characteristic of the cell which changes in response to substances which inhibit or activate the protein. Such responsive changes in a phenotypic characteristic may be utilized in many useful ways, including the discovery, development or characterization of substances suitable for the treatment of diseases or other conditions in human beings or animals. Such cells may also be useful for studying diseases or other biological processes, for determining the effects of various drugs alone or in combination, as well as for identifying or characterizing substances which may be useful in reducing or preventing the occurrence of a disease or other condition. Through the use of such cells in a cell based assay, tamoxifen is identified as an inhibitor of Protein Kinase C (PKC) activity in cell culture.
REFERENCES:
patent: 4980281 (1990-12-01), Housey
patent: 4981790 (1991-01-01), Haseltine et al.
patent: 5266464 (1993-11-01), Housey
Degen Nancy
ICT Pharmaceuticals, Inc.
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