Method of screening for pharmaceuticals by detecting cross...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S320100, C435S325000

Reexamination Certificate

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06855507

ABSTRACT:
Under the knowledge which two kinds of intracellular signal transfer mechanism of TGF-β super family receptor exist: a pathway via Smad molecule and a pathway via novel MAP kinase such as TAB1 and TAK1, and the knowledge of interaction of Smad molecule with intranuclear receptor or CBP/p300 on the transcription control by Smad molecule, a screening method and a molecular designing method for pharmaceuticals with identified site of action and higher specificity can be accomplished.

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