Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Reexamination Certificate
2005-06-14
2005-06-14
Kemmerer, Elizabeth (Department: 1647)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
C435S007100, C435S007200, C435S007210, C436S501000, C800S003000
Reexamination Certificate
active
06905815
ABSTRACT:
A method for screening substances which are useful as effective components of prophylactic or therapeutic drug for neurodegenerative diseases caused by the binding of an aberrant protein and a valosin-containing protein, wherein the aberrant protein and the valosin-containing protein and the candidate substance are made to coexist, and the substance that shows inhibitory action on the binding of the aberrant protein and the valosin-containing protein is identified, is provided.
REFERENCES:
American Heritage Dictionary of the English Language (downloaded from Dictionary.com Jan. 24, 2005).
American Heritage Dictionary of the English Language (2000).
Tobin & Signer (Dec. 2000) “Huntington's disease: the challenge for cell biologists.” Trends Cell Biol. 10(12): 531-536.
Barrow et al. (Jun. 20, 1992) “Solution conformations and aggregational properties of synthetic amyloid beta-peptides of Alzheimer's disease. Analysis of circular dichroism spectra.” J Mol Biol. 225(4): 1075-1093.
Johnstone et al. (Jul. 1991) “Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis.” Brain Res Mol Brain Res. 10(4): 299-305.
Sian et al. (1999) “Parkinson's disease: a major hypokinetic basal ganglia disorder.” J Neural Transm. 106(5-6): 443-476.
Egerton et al. (Oct. 1992) “VCP, the mammalian homolog of cdc48, is tyrosine phosphorylated in response to T cell antigen receptor activation.” EMBO J. 11(10): 3533-3540.
Dai & Li (Aug. 2001) “Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin-proteasome degradation.” Nat Cell Biol. 3(8): 740-744.
Zhang et al. (May 2000) “VCP, a weak ATPase involved in multiple cellular events, interacts physically with BRCA1 in the nucleus of living cells.” DNA Cell Biol. 19(5): 253-263.
National Library of Medicine (MeSH) (Jun. 4, 2004).
Kakizuka, Tanpakushitsu, Kakusan, Kouso, vol. 45, No. 6, pp. 792-797 (2000).
Kakizuka, Trend Genet., vol. 14, No. 10, pp. 396-402 (1998).
Rockel, FEBS Lett., 451(1), pp. 27-32 (1999).
Hirabayashi Miho
Kakizuka Akira
Japan Science and Technology Corporation
Kemmerer Elizabeth
Nichols Christopher James
Osaka Bioscience Institute
Wenderoth , Lind & Ponack, L.L.P.
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