Method of screening for attenuating viruses

Details Method of screening for attenuating viruses Method of screening for attenuating viruses

1997-06-13

2000-01-04

Lankford, Jr., Leon B.

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

435236, 435237, 435 5, 424 936, 4242181, L12N 500

Patent

active

060108940

ABSTRACT:
The present invention provides a method of selecting virus vaccine candidates by selecting virus variants that do not bind to brain membrane receptor preparations, comprising the steps of: (a) preparing a brain membrane receptor preparation; (b) mixing an amount of a virus of interest with an amount of said membrane receptor preparation containing excess membrane receptors to form a virus-membrane receptor preparation suspension; (c) centrifuging said suspension to form a supernatant; (d) determining residual virus infectivity in said supernatant; and (e) isolating individual membrane receptor preparation binding-resistant virus variants which are useful as virus vaccine candidates.

REFERENCES:
Cao et al. Journal of General Virology. vol. 76(11). pp. 2757-2764, 1995.

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