Method of screening for antimitotic compounds using the CDC25 ty

Details Method of screening for antimitotic compounds using the CDC25 ty Method of screening for antimitotic compounds using the CDC25 ty

1992-05-05

1994-03-15

Wax, Robert A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

435 691, 435 693, 435 697, 4351723, 435193, 435194, 4353201, 514 44, 536 221, 536 231, 536 232, 536 235, C12Q 142, C12P 2106, C07H 1900, C07H 2100

Patent

active

052945383

ABSTRACT:
A method of identifying compounds or molecules which alter (enhance or inhibit) stimulation of kinase activity of pre-MPF and, thus, alter (enhance or inhibit) activation of MPF and entry into mitosis. The present method thus makes it possible to identify compounds or molecules which can be administered to regulate the cell cycle; such compounds are also the subject of this invention.

REFERENCES:
Glover "Expression of cloned DNA in E. coli plasmid"in Gene Cloning 1984, pp. 110-129.
Gautier, J. et al., Cell, 67:197-211 (Oct. 4, 1991).
Dunphy, W. G. and A. Kumagai, Cell, 67:189-196 (Oct. 4, 1991).
Nagata, A. et al., The New Biologist, 3:959-968 (Oct., 1991).

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