Method of screening for Alzheimer's disease or disease associate

Details Method of screening for Alzheimer's disease or disease associate Method of screening for Alzheimer's disease or disease associate

1993-10-29

1998-03-31

Knode, Marian C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 721, 435 792, 435 4052, 435960, 436547, 436548, 436811, 5303879, 5303881, 5303891, G01N 3353, C07K 1618

Patent

active

057337349

ABSTRACT:
Substantially purified antibodies, including substantially purified monoclonal antibodies, which are specifically reactive with .tau. that has an abnormally phosphorylated serine in the sequence LysSerProVal SEQ ID NO:3 are disclosed. Methods of screening persons for diseases associated with pair helical filaments, including Alzheimer's disease, by detection of .tau. that has an abnormally phosphorylated serine in the sequence LysSerProVal SEQ ID NO:3 in test samples taken from such persons and test kits useful to perform such methods are disclosed.

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