Method of screening for agents to treat heart failure

Details Method of screening for agents to treat heart failure Method of screening for agents to treat heart failure

2008-11-22

2011-10-25

Schultz, Doug (Department: 1633)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

C435S006120, C514S04400A, C536S024500

Reexamination Certificate

active

08043801

ABSTRACT:
The invention provides a method of identifying candidate agents to test for treating heart failure involving diastolic impairment, the method comprising: testing an agent to determine whether it (a) binds to serum response factor (SRF), (b) reduces SRF binding to a serum response element (SRE), or (c) reduces SRF protein levels in a cell; wherein if the agent does one or more of (a), (b), and (c), it is identified as a candidate agent.

REFERENCES:
patent: 2006/0058237 (2006-03-01), Wei

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