Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals – Carrier is a biological cell or cell fragment
Reexamination Certificate
2007-12-10
2009-10-20
Spector, Lorraine (Department: 1647)
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
Carrier is a biological cell or cell fragment
C435S007210
Reexamination Certificate
active
07605005
ABSTRACT:
The invention relates to a pharmaceutical composition for treating or diagnosing a disorder associated with production of peroxisome in a cell, comprising a polypeptide which has cysteine protease activity and directly processes peroxisomal enzymes targeted by PTS1 or PTS2 signals. Preferably, the polypeptide is encoded by Tysnd1.
REFERENCES:
Keen Henry L. et al, “Gene expression profiling of potential PPARgamma target genes in mouse aorta,” Physiological Genomics, 18(17), 2004, 33-42, XP002404515 ISSN: 1094-8341 cited in the application table 6.
Beier K. et al., “Selective Induction of Peroxisomal Enzymes by the Hypolipidemic Drug Bezafibrate Detection of Modulations by Automatic Image Analysis in Conjunction With Immunoelectron Microscopy and Immunoblotting,” European Journal of Cell Biology, 46(3), 1988, 383-393, XP009073995 cited in the application abstract.
Kurochkin I.V. et al., “In Silico Prediction of Peroxisomal Proteins in Mouse,” Genome Informatics, 14, 2003, 539-540, XP002404518 Retrieved from the Internet: <URL:http>://www.jsbi.org/journal/GIW03/GIWO3p068.pdf> cited in the application.
Kurochikin Igor V. et al., “Sequence-based discovery of the human and rodent peroxisomal proteome,” Applied Bioinformatics. 4(2), 2005, 93-104, XP001247925 ISSN: 1175-5636 cited in the application.
Kurochkin I.V. et al, “Identification of Potential Peroxisomal Proteins in Mouse,” Genome Research, 15, 2003, p. 1560, XP002404517 Retrieved from the Internet: URL:http://www.genome.org/cgi/reprint/13/6b/1560> cited in the application.
Database EMBL Feb. 8, 2001, “Mus musculus adult male liver cDNA, Riken full-length enriched library, done: 1300019N10 product hypothetical protein, full insert sequence,” XP002404522 retrieved from EBI accession No. EM-PRO: AK005069 Database accession No. AK005069 & Carninci P et al: “High-Efficiency Full-Length CDNA Cloning” Methods in Enzymology, Academic Press Inc, San Diego, CA, US, vol. 303, 1999, pp. 19-44, XP001022979 ISSN: 0076-6879.
Subramani S. et al, “Import of peroxisomal matrix and membrane proteins,” Annual Review of Biochemistry, 69, 2000, 399-418, XP002404519 ISSN: 0066-4154 cited in the application.
Titorenko V. I. et al, “Dynamics of peroxisome assembly and function,” Trends in Cell Biology, Elsevier Science LTD, XX, 11(1), Jan. 2001, 22-29, XP002349975 ISSN: 0962-8924.
Gould S. J. et al., “Peroxisome biogenesis disorders—Genetics and cell biology,” Trends in Genetics, Elsevier, Amsterdam, NL, 16(8), Aug. 2000,340-345, XP004215200 ISSN: 0168-9525 cited in the application.
Kaiser E. et al., “Clinical Biochemistry of Peroxisomal Disorders,” Clinica Chemica Acta, 173(1) 1988, 57-80, XP002404520 & Selection of Papers on Progress in Clinical Enzymology Presented at the 12th International Symposium ISSN: 0009-8981.
Purdue P. E. et al. “Peroxisome biogenesis,” Annu Rev Cell Dev Biol. 2001;17:701-752 and Table of Contents (2 pages).
Olivier L. M. et al., “Identification of peroxisomal targeting signals in cholesterol biosynthetic enzymes,” AA-CoA thiolase, hmg-coa synthase, MPPD, and FPP synthase, J Lipid Res., 2000; 41(12):1921-1935.
Osumi, T. et al., “Amino-terminal presequence of the precursor of peroxisomal 3-ketoacyl-CoA thiolase is a cleavable signal peptide for peroxisomal targeting,” Biochem Biophys Res Commun. Dec. 31, 1991;181(3): 947-954.
Swinkels B. W. et al., “A novel, cleavable peroxisomal targeting signal at the amino-terminus of the rat 3-ketoacyl-CoA thiolase,” EMBO J., 1991; 10(11): 3255-3262.
Tsukamoto T. et al. “Characterization of the signal peptide at the amino terminus of the rat peroxisomal 3-ketoacyl-CoA thiolase precursor,” J Biol Chem., Feb. 25, 1994; 269(8): 6001-6010.
Hettema E. H. et al. “Import of proteins into peroxisomes,”Biochim Biophys Acta., Aug. 12, 1999; 1451(1): 17-34.
Titorenko V. I. et al., “The life cycle of the peroxisome,” Nat Rev Mol Cell Biol., May 2001; 2(5): 357-368 and correction page.
Titorenko V. I. et al., “The peroxisome: orchestrating important developmental decisions from inside the cell,” J Cell Biol., Mar. 1, 2004; 164(5): 641-645.
Cohen G. B. et al., “The human thioesterase II protein binds to a site on HIV-1 Nef critical for CD4 down-regulation,” J Biol Chem., Jul. 28, 2000 ;275(30): 23097-23105.
Gavva N. R. et al., “NAPP2, a peroxisomal membrane protein, is also a transcriptional corepressor,” Genomics., Mar. 2002; 79(3): 423-431.
I. J. van der Klei et al., “Yeast peroxisomes: function and biogenesis of a versatile cell organelle,” Trends Microbiol., Dec. 1997; 5(12): 502-509.
Veenhuis M. et al., “Peroxisome assembly in yeast,” Microsc Res Tech., Jun. 2003, 1;61(2):139-150.
Olsen L. J. et al., “The surprising complexity of peroxisome biogenesis,” Plant Mol Biol., Sep. 1998; 38(1-2): 163-189.
Hannaert V. et al., “Structure, function, and biogenesis of glycosomes in kinetoplastida,” J Bioenerg Biomembr. Apr. 1994; 26(2): 205-212.
Moyersoen J. et al. “Biogenesis of peroxisomes and glycosomes: trypanosomatid glycosome assembly is a promising new drug target,” FEMS Microbial Rev., 2004; 28(5): 603-643.
M. van de Kamp et al., “Compartmentalization and transport in beta-lactam antibiotic biosynthesis by filamentous fungi,” Antonie Van Leeuwenhoek., Jan.-Feb. 1999; 75(1-2): 41-78.
Kikuchi M. et al., “Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease,” J Biol. Chem., Jan. 2004, 279(1): 421-428.
Jansen G. A. et al., “Molecular basis of Refsum disease: sequence variations in phytanoyl-CoA hydroxylase (PHYH) and the PTS2 receptor (PEX7),” Hum Mutat. Mar. 2004; 23(3): 209-218.
Sacksteder K. A. et al., “The genetics of peroxisome biogenesis,” Annu Rev Genet 2000; 34: 623-652 & Table of Contents (2 pages).
Titorenko V. I. et al., “Pex20p of the yeast Yarrowia lipolytica is required for the oligomerization of thiolase in the cytosol and for its targeting to the peroxisome,” J Cell Biol. Jul. 27, 1998; 142(2):403-420.
Glover J. R. et al., “Saccharomyces cerevisiae peroxisomal thiolase is imported as a dimer,” Proc Nail Acad Sci U S A., Oct. 1994; 91: 10541-10545.
Leiper J. M. et al., “Inhibition of alanine: Glyoxylate aminotransferase 1 dimerization is a prerequisite for its peroxisome-to-mitochondrion mistargeting in primary hyperoxaluria type 1,” J Cell Biol. Nov. 1996; 135(4): 939-951.
Bellion E. et al., “Proton ionophores prevent assembly of a peroxisomal protein,” Cell. Jan. 16, 1987; 48(1): 165-173.
Waterham H. R. et al., “Peroxisomal targeting, import, and assembly of alcohol oxidase in Pichia pastoris,” J Cell Biol., Dec. 15, 1997; 139(6); 1419-1431.
Marzioch M. et al., “PAS7 encodes a novel yeast member of the WD-40 protein family essential for import of 3-oxoacyl-CoA thiolase, a PTS2-containing protein, into peroxisomes,” EMBO J. Oct. 17, 1994; 13(2); 4908-4918.
Albertini M. et al., “Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways,” Cell. Apr. 4, 1997; 89; 83-92.
Elgersma Y. et al., “A mobile PTS2 receptor for peroxisomal protein import in Pichia pastoris,” J Cell Biol., Feb. 23, 1998, 140(4); 807-820.
Szilard R. K. et al., “Pay32p of the yeast Yarrowia lipolytica is an intraperoxisomal component of the matrix protein translocation machinery,” J Cell Biol., Dec. 1995; 131(6); 1453-1469.
Zhang J. W. et al., “PEB1 (PAS7) in Saccharomyces cerevisiae encodes a hydrophilic, intra-peroxisomal protein that is a member of the WD repeat family and is essential for the import of thiolase into peroxisomes,” J Ce
Kurochkin Igor
Okazaki Yasushi
Schoenbach Christian
Edwards Angell Palmer & & Dodge LLP
Riken
Saitama Medical University
Spector Lorraine
Stoica Elly-Gerald
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