Method of screening compounds for controlling capacitative calci

Details Method of screening compounds for controlling capacitative calci Method of screening compounds for controlling capacitative calci

1996-10-15

1999-08-03

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 691, 4351723, 435325, 435375, 536 231, 536 245, C12Q 168, C12N 1500, C12N 1585, C07H 2104

Patent

active

059324171

ABSTRACT:
A method for controlling capacitative calcium ion entry into a mammalian cell. The method is based on the discovery that mammalian transient receptor potential (trp) protein are essential for calcium ion entry. Two human trp proteins are disclosed. Htrp1 and Htrp3. The method involves treating cells with a trp-control agent to either raise or lower the amount of biologically active trp protein associated with the cell to thereby control capacitative calcium ion entry into the cell. Screening methods are also disclosed based upon using mammalian trp protein as a screening target.

REFERENCES:
patent: 5670330 (1997-09-01), Sonenberg et al.
Vaca et al., Activation of recombinant trp by thapsigargin in sf9 insect cells, American Journal of Physiology, vol. 267 (5, pt.1), pp. c1501-1505, 1994.
Verma et al., Gene therapy-promises, problems and prospects, Nature, vol. 389, pp. 239-242, Sep. 18, 1997.
Zhu et al., Molecular cloning of a widely expressed human homologue for the Drosophila trp gene, FEBS Letters, vol. 373, pp. 193-198, Oct. 1995.
Mulligan, The basic science of gene therapy, Science, vol. 260, pp. 926-932, May 14, 1993.
Wes et al., TRPC1, a human homolog of a Drosophila store-operated channel, Proc. Natl. Acad. Sci., vol. 92, pp. 9652-9656, Oct. 1995.

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