Multicellular living organisms and unmodified parts thereof and – Method of using a transgenic nonhuman animal in an in vivo...
Reexamination Certificate
2006-02-01
2009-12-01
Krouch, Deborah (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Method of using a transgenic nonhuman animal in an in vivo...
C800S018000, C435S455000
Reexamination Certificate
active
07626074
ABSTRACT:
Transgenic non-human mammals that reproduce human pathologies of stem cell origins, such as chromosomal anomalies associated with chronic myeloid leukemia, B-cell acute lymphoblastic leukemia, T-cell acute or lymphoblastic leukemia, or with the migration of hematopoietic or embryonic stem cells are provided. The transgenic non-human mammals can be produced using as a strategy the expression of genes involved in pathologies by a promoter that directs the expression of a transgene in Sca-1+cells. The transgenic animals constitute a model for the study of diseases and for the evaluation of compounds for the treatment and/or prevention of the diseases. DNA construct and methods useful for producing the non-human transgenic mammals are also provided.
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Garcia Isidro Sanchez
Losada Jesus Perez
Consejo Superior de Investigaciones Cientificas
Krouch Deborah
McWhinney Christopher T.
Singh Anoop
Sullivan & Worcester LLP
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