Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...
Patent
1989-04-06
1989-10-10
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Identification or warning feature
Taste or smell or chemical irritation to the eye, nose, or...
514220, 514221, 514282, 514329, 514330, 514922, A61K 3144, A61K 3155, A61K 31445, A61K 4700
Patent
active
048730769
ABSTRACT:
A method of inducing anesthesia or conscious sedation while avoiding serious hypotensive episodes comprising the administration of a parenterally active benzodiazpine in conjunction with an opiate analgesic followed by the parenteral administation of from about 1 to about 3 mg of a long-acting pure narcotic antagonist. The antogonist may be administered during the time interval commencing immediately prior to the procedure and continuing until about 3-5 hours after administration of the opiate-benzodiazepine combination.
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Craig et al., Modern Pharmacology .COPYRGT.1982, 1st. ed. p. 566.
Heilman et al., Research Comm. in Chem. Path & Pharm. vol. 13, No. 4 (4/76), pp. 635-647.
Avery's Drug Treatment, 3rd ed., 1987, pp. 318-319 and 350.
Sawynok et al., Life Sci., 25:1621-1632 (1979).
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Bell, J. Pediatrics, 87:803-804 (1975).
Patschke et al., Br. J. Anesth., 49:525 (1977).
Forster et al., Anesth. Analg., 62:920-924 (1983).
Arnold John
Fishman Jack
Hsiao Jane
Sherman Fred
Baker Cummins Pharmaceuticals, Inc.
Henley III Raymond J.
Robinson Douglas W.
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