Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1990-01-18
1992-07-07
Wax, Robert A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 21, A61K 3736
Patent
active
051283204
ABSTRACT:
A method is disclosed for at least partially restoring normal growth, weight gain, and lean body mass of a mammal afflicted with glucocorticoid excess. This method comprises the administration to the mammal of an effective amount of IGF-I. Preferably, the mammal is a child and the IGF-I is native-sequence or brain IGF-I.
REFERENCES:
patent: 4988675 (1991-01-01), Froesch et al.
Fagin et al. (Jun. 1989) Endocrine Soc. Annual Meeting, Abstraact No. 1666.
Luo et al. (Jul. 1989) Endocrinology 125:165-171.
Scheiwiller et al. (1986) Nature 323:169-171.
Schalch et al. (1989, Apr. 28) Biochem. Biophys. Res. Comm. 160(2):795-800.
Guler et al., N. Engl. J. Med., 317(3):137-140 (1987).
Guler et al., Endocrinology, 118: Supp. 129 abstract.
Skottner et al., Endocrinology, 124(5):2519-2526 (1989).
van Buul-Offers et al., Pediatr. Res. 20(9):825-837 (1986).
Loeb, N. Engl. J. Med. 295(10):547-552 (1976).
McArthur et al., Mayo Clin. Proc. 47:318-326 (1972).
Monro, in Mammalian Protein Metabolism, eds. Monro and Allison (Academic Press, Inc., New York, 1964) p. 381.
Soyka and Crawford, J. Clin. Endocrinol. Metab., 25:469-475 (1965).
Nicholson et al., Neuroendocrinology, 39:343-349 (1984).
Luo and Murphy, Endocrinology, 125(1):165-171 (1989).
Wehrenberg et al., Science 221:556-558 (1983).
Oosterom et al., Endocrinology, 113(2):735-741 (1983).
Hofert et al., Metabolism, 38(6):594-600 (1989).
Conover et al., In Vitro Cell. & Dev. Biol., 25(6):521-527 (1989).
Elders et al., Am. J. Dis. Child., 129:1393-1396 (1975).
Unterman & Phillips, J. Clin. Endocrin. & Metab., 61:618-626 (1985).
Reid et al., Clin. Endocr., 30:347-353 (1989).
Hahn Theodore J.
Rudman Christopher G.
Ekstrom Richard C.
Genentech Inc.
Hasak Janet E.
Wax Robert A.
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