Method of resolution of hydroxy substituted cyclopentanone enant

Details Method of resolution of hydroxy substituted cyclopentanone enant Method of resolution of hydroxy substituted cyclopentanone enant

1994-01-24

1995-09-05

Knode, Marian C.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435136, C12P 4100

Patent

active

054478650

ABSTRACT:
A method for the resolution of optically active compounds from racemic mixtures is provided. In one embodiment of the method, racemic substituted cyclopentenones, useful as eicosanoid intermediates, are enzymatically resolved with lipase and separated by formation of lithium salt complexes. In another embodiment of the method, optically active alcohols are obtained from prochiral halovinyl ketones or alkynyl ketones by selective catalytic reduction with chiral boronic catalysts. In yet another embodiment of the method, prostaglandin E.sub.1 are produced from prostaglandin E.sub.1 esters by selective ester hydrolysis with a lipase.

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