Surgery – Liquid medicament atomizer or sprayer
Patent
1998-04-29
2000-08-08
Lewis, Aaron J.
Surgery
Liquid medicament atomizer or sprayer
12820022, 12820312, 12820423, A61M 1100
Patent
active
060986158
ABSTRACT:
Devices, packaging and methodology for efficiently and repeatably creating aerosolized bursts of an insulin containing formulation are disclosed. Devices are hand-held, self-contained units which are automatically actuated at the same release point in a patient's inspiratory flow cycle. The release point is automatically determined either mechanically or, more preferably calculated by a microprocessor which receives data from a sensor making it possible to determine inspiratory flow rate and inspiratory volume. The device is loaded with a cassette comprised of an outer housing which holds a package of individual disposable collapsible containers of an insulin containing formulation for systemic delivery. Actuation of the device forces insulin formulation through a porous membrane of the container which membrane has pores having a diameter in the range of about 0.25 to 3.0 microns, preferably 0.25 to 1.5 microns. The porous membrane is positioned in alignment with a surface of a channel through which a patient inhales air. The flow profile of air moving through the channel is such that the flow at the surface of the channel is less than the flow rate at the center of the channel.
REFERENCES:
patent: 3812854 (1974-05-01), Michaels et al.
patent: 3991304 (1976-11-01), Hillsman
patent: 4106503 (1978-08-01), Rosenthal et al.
patent: 4343798 (1982-08-01), Fawri
patent: 4361401 (1982-11-01), Smith et al.
patent: 4468464 (1984-08-01), Cohen et al.
patent: 4604847 (1986-08-01), Moulding, Jr. et al.
patent: 4624251 (1986-11-01), Miller
patent: 4627432 (1986-12-01), Newell et al.
patent: 4639435 (1987-01-01), Fujii et al.
patent: 4677975 (1987-07-01), Edgar et al.
patent: 4686231 (1987-08-01), Bender et al.
patent: 4727028 (1988-02-01), Santerre et al.
patent: 4755383 (1988-07-01), Fujii et al.
patent: 4819629 (1989-04-01), Jonson et al.
patent: 4877989 (1989-10-01), Drews et al.
patent: 4926852 (1990-05-01), Zoltan et al.
patent: 4984158 (1991-01-01), Hillsman
patent: 5006343 (1991-04-01), Benson et al.
patent: 5011678 (1991-04-01), Wang et al.
patent: 5167506 (1992-12-01), Kilis et al.
patent: 5198541 (1993-03-01), Elsbach et al.
patent: 5284133 (1994-02-01), Burns et al.
patent: 5320094 (1994-06-01), Laube et al.
patent: 5333106 (1994-07-01), Lanpher et al.
patent: 5363842 (1994-11-01), Mishelevich et al.
patent: 5364838 (1994-11-01), Rubsamen
patent: 5394866 (1995-03-01), Ritson et al.
patent: 5404871 (1995-04-01), Goodman
patent: 5437267 (1995-08-01), Weinstein et al.
patent: 5446020 (1995-08-01), Andy et al.
patent: 5450336 (1995-09-01), Rubsamen et al.
patent: 5497944 (1996-03-01), Weston et al.
patent: 5509404 (1996-04-01), Lloyd et al.
patent: 5514646 (1996-05-01), Chance et al.
patent: 5522385 (1996-06-01), Lloyd et al.
patent: 5544646 (1996-08-01), Lloyd et al.
patent: 5547929 (1996-08-01), Anderson, Jr. et al.
patent: 5693608 (1997-12-01), Bechgaard et al.
patent: 5700662 (1997-12-01), Chance et al.
patent: 5743250 (1998-04-01), Gonda et al.
Barker et al., "Acidic Precursor Revealed in Human Eosinophil Granule Major Basic Protein cDNA," J. Exp. Med., 168:1493-1498 (1988).
Collins et al., "Continous Growth and Differentiation of Human Myeloid Leukaemic Cells in Suspension Culture," Nature, 270:347-349 (1977).
Drazin et al., "Fungicidal Properties of a Chymotrypsin-Like Cationic Protein from Human Neutrophils: Absorption to Candida parapsilosis," Infect. Immun., 17:382-388 (1977).
Elsbach et al., "Separation and Purification of a Potent Bactericidal/Permeability-Increasing Protein and a Closely Associated Phospholipase A.sub.2 from Rabbit Polymorphonuclear Leukocytes," The Journal of Biological Chemistry, 254:11000-11009 (1979).
Elsbach et al., "Bactericidal/Permeability Increasing Protein (BPI) of Granulocytes: Structure and Function," Bacteria-Host Cell Interaction, 47-60 (1988).
Farley et al., "Antimicrobial Binding of a Radiolabeled Cationic Neutrophil Granule Protein," Infection and Immunology, 55:1536-1539 (1987).
Gabay et al., "Antibiotic Proteins of Human Polymorphonuclear Leukocytes," Proc. Natl. Acad. Sci., USA, 86:5610-5614 (1989).
Gabay et al., "Azurophil-derived Bactericidal Factor(s) from Human Neutrophils," Clinical Research, 34:676A (1986).
Gabay et al., "Subcellular Location and Properties of Bactericidal Factors from Human Neutrophils," J. Exp. Med., 164:1407-1421 (1986).
Ganz et al., "Defensins: Natural Peptide Antibiotics of Human Neutrophils," J. Clin. Invest., 76:1427-1435 (1985).
Gray et al., "Cloning of the cDNA of a Human Neutrophil Bactericidal Protein," The Journal of Biological Chemistry, 264:9505-9509 (1989).
Gray et al. "Cloning of the Gene of the Human Bactericidal/Permeability Increasing Protein and Identification of Structure-Function Relationships," Clinical Research, 36:620A (1988).
Gubler et al., "A Simple and Very Efficient Method for Generating cDNA Libraries," Gene, 25:263-269 (1983).
Heck et al., "Isolation, Characterization, and Amino-Terminal Amino Acid Sequence Analysis of Human Neutrophil Elastase from Normal Donors," Anal. Biochem., 149:153-162 (1985).
Heck et al., "Isolation, Characterization, and Amino-Terminal Amino Acid Sequence Analysis of Human Neutrophil Cathepsin G from Normal Donors," Anal. Biochem., 158:217-227 (1986).
Heron, "System for Automated DNA Synthesis," American Biotechnology Laboratory, 2:52-54, 56, 58-59 (1984).
Hovde et al., "Physiological Effects of a Bactericidal Protein from Human Polymorphonuclear Leukocytes on Pseudomonas aeruginosa," Infect. Immun., 52:90-95 (1986).
Hovde et al., "Characterization of a Protein from Normal Human Polymorphonuclear Leukocytes with Bactericidal Activity against Pseudomonas aeruginosa," Infect. Immun., 54:142-148 (1986).
Hunkapiller et al., "High-Sensitivity Sequencing with a Gas-Phase Sequenator," Meth. Enzymol., 91:399-413 (1983).
Klein, Immunology: The Science of Self-Nonself Discrimination. John Wiley & Sons, NY. p. 101 (1982).
Larrick et al., "Complementary DNA Sequence of Rabbit Cap 18--A Unique Lipopolysaccharide Binding Protein," Biochem. Biophys. Research Communications 179:170-175 (1991).
Lehrer et al., "Correlation of Binding of Rabbit Granulocyte Peptides to Candida albicans with Candidacidal Activity", Infect. Immun., 49:207-211 (1985).
Maniatis et al., (eds.) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY. pp. 188-199 (1982).
Muello et al., "The Role of Endotoxin in the Action of the Bactericidal/Permeability Increasing Neutrophil Protein on the Bacterial Envelope," Clinical Research, 31:371A (1983).
Nachman et al., "Studies on Isolated Membranes of Azurophil and Specific Granules from Rabbit Polymorphonuclear Leukocytes," J. Cell Biol., 54:133-140 (1972).
Odeberg et al., "Mechanisms for the Microbicidal Activity of Cationic Proteins of Human Granulocytes," Infect. Immun., 14:1269-1275 (1976).
Odeberg et al., "Antibacterial Activity of Cationic Proteins from Human Granulocytes," J.Clin. Invest., 56:1118-1124 (1975).
Okayama et al., "A cDNA Cloning Vector that Permits Expression of cDNA Inserts in Mammalian Cells," Molec. Cell Biol., 3:280-289 (1983).
Olsson et al., "Cationic Proteins of Human Granulocytes. II. Separation of the Cationic Proteins of the Granules of Leukemic Myeloid Cells," Blood, 44:235-246 (1974).
Ooi et al., "A 25-kDa NH.sub.2 -terminal Fragment Carries All the Antibacterial Activites of the Human Neutrophil 60-kDa Bactericidal/Permeability-Increasing Protein," J. Biol. Chem., 262:14891-14894 (1987).
Ooi et al., "Endotoxin-Neutralizing Properties of the 25 kD N-Terminal Fragment and a Newly Isolated 30kD C-Terminal Fragment of the 55-60 kD Bactericidal/Permeability-Increasing Protein of Human Neutrophils," J. Exp. Med., 174:649-655 (1991).
Pereira et al., "The Ontogeny of a 57-Kd Cationic Antimicrobial Protein of Human Polymorphonuclear Leukocytes: Localization to a Novel Granule Population," Blood, 76:825-834 (1990).
Rest et al., "Bactericidal Activity of Specific and Azurophil Granules from Human neutrophils: Studies with Outer-Membrane Mutants of Salmonella Typhimurium Lt-2," Infect. Immun., 19:
Lloyd Lester J.
Lloyd Peter M.
Rubsamen Reid M.
Schuster Jeffrey A.
Aradigm Corporation
Bozicevic Karl
Lewis Aaron J.
LandOfFree
Method of reproducibly effecting a patient's glucose level does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of reproducibly effecting a patient's glucose level, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of reproducibly effecting a patient's glucose level will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1140461