Method of repelling insects

Details Method of repelling insects Method of repelling insects

2002-06-21

2004-10-05

Pak, John (Department: 1616)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ketone doai

C514S919000, C424SDIG001, C504S101000, C504S348000

Reexamination Certificate

active

06800662

ABSTRACT:

FIELD OF THE INVENTION
The present invention concerns methods and formulations for repelling insects, particularly for repelling mosquitoes and ticks.
BACKGROUND OF THE INVENTION
Insect repellants are widely used throughout the United States and throughout the world. In some regions, the use of insect repellants is critical to avoiding or reducing the occurrence of disease carried by insects. For example the Centers for Disease Control (CDC) receives nearly 10,1000 reports of Lyme disease (transmitted by deer ticks) and 1,000 reports of encephalitis (transmitted by mosquitoes) annually).
Currently, the most common insect repellent is N,N-diethyl-meta-toluamide (DEET). DEET was designed to be applicable to the skin of subjects, and is designed to repel rather than kill insects. Although in use for some time, concern has recently emerged about the potential toxicity of DEET to children. Recently the US Environmental Protection Agency (EPA) determined that it would no longer allow child safety claims on labels for DEET-containing products.
The United States EPA Facts: Methyl Nonyl Ketone (July 1995) describes methyl nonyl ketone as a dog and cat repellent/training aid and iris borer deterrent, but does not suggest its use as an insect repellent.
U.S. Pat. No. 2,283,471 to Swaine describes the use of compounds such as methyl nonyl ketone and methyl undecyl ketone as contact insecticides for aphids and similar piercing-sucking insects (all primitive plant-feeding insects) which require contact insecticides for their control, but does not suggest their use as insect repellents.
R. Linderman et al.,
Pesticide Biochemistry and Physiology
35, 291-299 (1989), describes the inhibition of insect juvenile hormone esterase by &agr;,&bgr;-unsaturated and &agr;-acetylenic trifluoromethyl ketones, but does not suggest the use thereof as insect repellents.
Accordingly, there remains a need for new ways to repel insects, particularly mosquitoes and ticks.
SUMMARY OF THE INVENTION
Accordingly, the present invention provides a method of repelling an insect pest, comprising applying to a subject or substrate, in an amount effect to repel the insect pest, a compound of Formula I:
wherein R is C4-C20 linear or branched alkyl, preferably linear and preferably C7 to C13 alkyl.
Particularly preferred insects for application of the present method are mosquitoes, ticks and cockroaches.
In one preferred embodiment, the insect for application of the present method is a thrip.
In another embodiment, the insect for application of the present method is a biting fly such as a deer fly.
In another embodiment, the insect for application of the method of the present invention is a gnat.
In another embodiment, the insect for application of the method of the present invention is an aphid.
Further aspects of the present invention include compositions comprising compounds of Formula (I), or other active compounds, in combination with carriers or other ingredients for repelling insects, and the use of compounds of Formula (I) or active compounds disclosed herein for the preparation of a composition for repelling insects.


REFERENCES:
patent: 2283471 (1942-05-01), Swaine et al.
patent: 4562794 (1986-01-01), Speckman
patent: 5587401 (1996-12-01), VanderMeer et al.
patent: 6258857 (2001-07-01), Iijima et al.
patent: 6437001 (2002-08-01), Roe
patent: 9-30906 (1997-02-01), None
patent: WO 98/53678 (1998-12-01), None
patent: WO98/53678 (1998-12-01), None
Chemical abstract 126:208547 (1997).*
Linderman, Russell J., et al.,Inhibition of Insect Juvenile Hormone Esterase by &agr;,&bgr;-Unsaturated and &agr;-Acetylenic Trifluoromethyl Ketones, Pesticide Biochemistry and Physiology, vol. 35, pp. 291-299 (1989).
Rochat, Didier, et al.,Identification of Pheromone Synergists in American Palm Weevil, Rhynchophorus palmarum, and Attraction of Related Dynamis borassi, J. Chem. Ecol, vol. 26(1), pp. 155-187 (2000).
Renou, M., et al.,Effects of Trifluoromethyl Ketones and Related Compounds on the EAG and Behavioural Responses to Pheromones in Male Moths, Chem. Senses, vol. 22(4), pp. 407-416 (1997).
Rosell, Gloria, et al.,New Trifluoromethyl Ketones as Potent Inhibitors of Esterases:19F NMR Spectroscopy of Transition State Analog Complexes and Structure-Activity Relationships, Biochemical and Biophysical Research Communications, vol. 226, pp. 287-292 (1996).
Yoshizawa, Takumi et al.,Attractancy of Some Methyl Ketones Isolated from Cheddar Cheese for Cheese Mites, Bochu-Kagaku, vol. 35(2), pp. 43-45 1970).
Szauman-Szumski, K.J., et al.,Identification of chemicals attractive to the olive bark beetle, Phloeotribus scarabaeoides, in laboratory bioassays, vol. 43, pp. 345-355 (1998).
Chemical Abstracts, 125:208547, Abstracting JP 9-30906 (1997).
CABA Abstract, Accession No. 86:48796 (1985).
Du, Y. J., et al.,Electroantennogram and oviposition bioassay responses of Culex quinquefasciatus and Culex tarsalis . . . ,Journal of Medical Entomology, vol. 36, No. 2, pp. 158-166 (1999).
Kramer, K.J, et al., Abstract,Effects of 2-tridecanone and analogues on the reproduction and mortality of stored product insects, Journal of the Kansas Entomological Society, vol. 58, No. 2, pp. 254-260.
Sakata, Naohiro, et al., Abstract,Long-lasting insect repellents containing 2-undecanone and their mats, Chemical Abstracts, vol. 126, No. 16, pp. 189 (1997).
Du, et al.,Electroantennogram and Oviposition Bioassay Responses of Culex quinquefasciatus and Culex tarsalis(Diptera: Culicidae)to Chemicals in Odors from Bermuda Grass Infusions, Journal of Medical Entomology, vol. 36, No. 2, pp. 158-166 (1999).
International Search Report for International Application Ser. No. PCT/US02/07620 dated Sep. 26, 2002.

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