Method of removing formyl groups from N-formyl-amino acid and N-

Details Method of removing formyl groups from N-formyl-amino acid and N- Method of removing formyl groups from N-formyl-amino acid and N-

1976-08-10

1978-01-31

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

560171, C07C10352

Patent

active

040715116

ABSTRACT:
The masking N-formyl group of an N-formyl-amino acid ester or an N-formyl-peptide ester having a free carboxyl group is removed without major side reactions when the ester is contacted with a strong acid in a mixture of water and a specific organic solvent such as methyl ethyl ketone or acetonitrile. This method is specifically applicable to the production of L-aspartyl amino acid lower alkyl esters which are known as low calorie sweeteners.

REFERENCES:
patent: 3933781 (1976-01-01), Bachman et al.
patent: 4021418 (1977-05-01), Takemoto et al.
Sondheimer, et al; J. Am. Chem. Soc. 26, 1961, pp. 1847-1849.
Sheehan, et al; J. Am. Chem. Soc. 80, 1958, pp. 1154-1158.
Greenstein, et al; Chemistry of the Amino Acids 2, 1961, pp. 1246-1247, 1283-1284, 1294.

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