Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1979-08-03
1981-07-21
Breitenstein, G. T.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
26050111, A61K 31205, C07C10124
Patent
active
042799260
ABSTRACT:
The present invention provides a method of relieving pain and of treating inflammatory conditions in warm-blooded animals, including humans, which comprises administering to a warm-blooded animal suffering from an inflammatory condition a phenyl-alkanoic acid salt of the general formula: ##STR1## wherein R.sub.1 is a hydrogen atom or a methyl radical, R.sub.2 is a halogen atom or an alkyl radical containing up to 5 carbon atoms, which may be straight-chained or branched, for example an isobutyl radical, or is a cyclohexyl radical or is a phenoxy or benzoyl radical, which may be substituted by one or two halogen atoms, R.sub.3 is a hydrogen atom or an allyloxy radical or R.sub.2 and R.sub.3, together with the phenyl nucleus to which they are attached, represent a naphthyl ring system containing a methoxy substituent, B is a primary, secondary or tertiary amino group or a guanidino or amidino group and n is a whole number not greater than 5, for example B is an amino group and n is 3 (ornithine), B is an amino group and n is 4 (lysine) or B is a guanidino radical and n is 3 (arginine).
REFERENCES:
patent: 3624142 (1971-11-01), Shen
patent: 3686183 (1972-08-01), Depon
patent: 3821289 (1974-06-01), Diamond
patent: 3931302 (1976-01-01), Allais et al.
patent: 4001301 (1977-01-01), Fried et al.
Chemical Abstracts, 76, 6721(b), 1972.
Bruzzese Tiberio
Ferrari, deceased Rodolfo
Breitenstein G. T.
SPA--Societa Prodotti Antibiotici S.p.A.
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