Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1998-04-15
2000-01-11
Reamer, James H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 21, 514 23, 514414, 514440, 514909, 426 72, 426656, 426658, A61K 3100
Patent
active
060136227
ABSTRACT:
Methods and compositions capable of controlling weight in an animal, preferably a human, which methods involve administering diet compositions that modulate, and preferably reduce, synthesis and secretion of neuropeptide Y (NPY) and modulate, and preferably increase synthesis and secretion of growth hormone releasing factor (GRF), compared to pre-administration amounts in the animal. The administration of such diet compositions results in a reduced appetite and a regulated metabolism that enhance weight control, including weight loss and reduction of obesity.
REFERENCES:
patent: 5480865 (1996-01-01), Kingham et al.
D. Larhammar, "Evolution of neuropeptide Y, peptide YY and pancreatic polypeptide," Regulatory Peptides, 62:1-11 (1996).
White, "Neuropeptide Y: a central regulator of energy homeostasis," Regulatory Peptides, 49:93-107 (1993).
Sanacora et al., "Increased hypothalamic content of preproneuropeptide Y messenger ribonucleic acid in genetically obese Zucker rats and its regulation by food deprivation," Endocrinology, 127(2):730-737 (1990).
Sanacora et al., "Developmental aspect of differences in hypothalamic preproneuropeptide Y messenger ribonucleic acid content in lean and genetically obese Zucker rats," J. Neuroendocrinol., 4(3):353-357 (1990).
White and Kershaw, "Increase hypothalamic neuropeptide Y expression following food deprivation," Molec. & Cell. Neurosci., 1:41-48 (1990).
Sahu, et al. "Neuropeptide Y gene expression in rats on scheduled feeding regimen," Molecular Brain Research, 15:15-18 (1992).
Berelowitz et al., "Regulation of hypothalamic neuropeptide expression by peripheral metabolism," TEM 3(4):127-133 (1992).
White et al., "Localization of prepro-growth hormone releasing factor mRNA in rat brain and regulation of its content by food deprivation and experimental diabetes," Molec. & Cell. Neurosci., 1:183-192 (1990).
Bruno et al., "Influence of food deprivation in the rat on hypothalamic expression of growth hormone-releasing factor and somatostatin," Endocrinology, 127(5):2111-2116 (1990).
NIH Technology Assessment Conference Panel, "Methods for voluntary weight loss and control," Ann. Intern. Med., 116:942-949 (1992).
Wadden, "Treatment of Obesity by moderate and severe caloric restriction," Ann. Intern. Med., 119:688-693 (1993).
Bruno et al., "Regulation of rat hypothalamic preprogrowth hormone-releasing factor messenger ribonucleic acid by dietary protein," Endorcinology, 129(3):1226-1232 (1991).
Bruno et al., "Regulation of hypothalamic preprogrowth hormone-releasing factor messenger ribonucleic acid expression in food-deprived rats: A role for histaminergic neurotransmission," Endocrinology, 133(3):1377-1381 (1993).
Latham and Blundell, "Evidence for the effect of tryptophan on the pattern of food consumption in free feeding and food deprived rats," Life Sciences, 24:1971-1978 (1979).
E. Jequier, "Energy, obesity, and body weight standards," Am. J. Clin. Nutr., 45:1035-47 (1987).
C. Dieguez, M.D. Page and M.F. Scanlon, "Growth hormone neuroregulation and its alterations in disease states," Clinical Endocrinology, 28:109-143 (1988).
Katch and McArdle: Nutrition, Weight Control, and Exercise, 3rd ed., Lea & Ferbiger, Philadelphia (1988).
M. Berelowitz et al., "Effects of growth hormone excess and deficiency on hypothalamic somatostatin content and release and on tissue somatostatin distribution," Endocrinology 109:714-719 (1981).
J.D. White et al., "Measurement of neuroendocrin peptide mRNA in discrete brain regions," Methods in Enzymology, P.M. Conn (Ed.), Academic Press, Orlando, FL, 124:548-560 (1986).
H. Higuchi et al., "Rat neuropeptide Y precursor gene expression," J. Biol. Chem. 263:6288-6295 (1988).
J.F. Bruno et al., "Regulation of rat hypothalamic preprogrowth hormone-releasing factor messenger ribonucleic acid by dietary protein," Endocrinology 129(3):1226-1232 (1991).
K.E. Mayo et al., "Characterization of cDNA and genomic clones encoding the precursor to rat hypothalamic growth hormone-releasing factor," Nature 314:464-467 (1985).
J.D. White et al., "Increased Hypothalamic Content of Preproneuropeptide-Y Messenger Ribonucleic Acid in Streptozotocin-Diabetic Rats," 126(2):765-772 (1990).
P. Ponsalle et al., "Glucocorticoids are Required for Food Deprivation-Induced Increases in Hypothalamic Neuropeptide Y Expression," 4(5):585-591 (1993).
Berelowitz Michael
Bruno John F.
Heil Matthew
Tripodi Daniel
White Jeffrey
Nutriceutical Technology Corporation
Reamer James H.
Research Foundation of State University of New York
LandOfFree
Method of regulating appetite and metabolism does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of regulating appetite and metabolism, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of regulating appetite and metabolism will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1462390