Method of reducing toxicity of retinoids

Details Method of reducing toxicity of retinoids Method of reducing toxicity of retinoids

2006-10-24

2006-10-24

Carr, Deborah D. (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Fatty compounds having an acid moiety which contains the...

Reexamination Certificate

active

07126017

ABSTRACT:
A method of minimizing or reducing the toxicity of a retinoid having a free carboxyl group is described. The method comprises the step of esterifying the carboxyl group of the retinoid with a highly sterically hindered compound, which is preferably an alcohol. The resulting retinoid esters are rendered much less toxic than the starting or parent retinoid. This process provides a retinoid ester analog of reduced toxicity so that it may be administered orally with minimal side effects and with a much greater therapeutic window.

REFERENCES:
patent: 4216224 (1980-08-01), Yu et al.
patent: 4677120 (1987-06-01), Parish et al.
patent: 4885311 (1989-12-01), Parish et al.
patent: 4994491 (1991-02-01), Purcell et al.
patent: 5049584 (1991-09-01), Purcell et al.
patent: 5124356 (1992-06-01), Purcell et al.
patent: 5837728 (1998-11-01), Purcell
patent: 2050658 (1972-05-01), None
patent: WO92/12989 (1992-08-01), None
Chem. Abstr. of JP-50/076047, 1975.
Salo, M. et al: “Biological Activity and Enzymic Hydrolysis of Retinoates in Vitro” European Journal of Pharmaceutical Sciences, vol. 3, No. 2, 1995, pp. 71-76, XP002286049.
Loeliger P. et al: “Arotinoids, A New Class of Highly Active Retinoids” European Journal of Medicinal Chemistry, Editions Scientifique Elsevier, Parts, FR, vol. 15, No. 1, 1980, pp. 9-15, XP002004638.
Tsutsumi, Yoichi: “Positive-Type Resist Composition with Good Dry-Etching Resistance for Far Ultraviolet Ray and Manufacture of Semiconductor Integrated Circuit Using It”, Database Caplus, Chemical Abstracts Services, Columbus, OH, XP002286050.

Affiliated with

Also associated with

Rating

Method of reducing toxicity of retinoids does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of reducing toxicity of retinoids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of reducing toxicity of retinoids will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3638684