Method of reducing tissue damage at an inflammatory site using a

Details Method of reducing tissue damage at an inflammatory site using a Method of reducing tissue damage at an inflammatory site using a

1987-06-11

1989-06-20

Moskowitz, Margaret

Drug, bio-affecting and body treating compositions

Lymphokine

530387, 530380, 530806, 43524027, 435 68, A61K 39395

Patent

active

048407933

ABSTRACT:
A method of reducing tissue injury in humans or other animal species using a monoclonal antibody to inhibit specific phagocyte functions. The monoclonal antibody is selected to bind to phagocytic leukocytes for the purpose of inhibiting migration to an inflammatory site in the body and to inhibit the adhesion and spreading of activated leukocytes reaching such an area and then, block release of toxic substances by these cells. The monoclonal antibody is administered in vivo prior or early in the course of an experience leading to an injurious inflammatory response such as can result from restoration of myocardial blood flow interrupted by an acute coronary thrombosis.

REFERENCES:
Arnaout et al., J. Clin. Invest., 72: 171-9, 1983.
Todd et al., J. Immunol., 126(4), 1435-42, 1981.
Todd et al., Hybridoma, 1(3), 329-37, 1982.
Te Velde et al., Chem. Abs., 104: 184712d, 1986.
Todd et al., J. Clin. Invest., 74, 1280-90, 1984.
Arnaout et al., Federation Proc., 44(10), 2664-69, 1985.

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