Method of reducing the severity of host vs graft reaction by dow

Details Method of reducing the severity of host vs graft reaction by dow Method of reducing the severity of host vs graft reaction by dow

1996-08-30

1999-11-30

Caputa, Anthony C.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Animal or plant cell

4241851, 4242831, 514 12, 514 21, A61K 3900, A61K 3800, A01N 6300

Patent

active

059938030

ABSTRACT:
A method for reducing the severity of host vs graft reaction (HVGR) by the transplant recipient of donor organ or tissue by the transplant recipient and is based on the discovery that hsp60 autoimmunity can function as an accelerator of foreign immunity and the down-regulation of hsp60 autoimmunity suppresses or prevents the graft rejection reaction. Administration of any composition which causes the down-regulation of hsp60 autoimmunity, such as hsp60 or peptide p277 in a tolerogenic carrier or a biologically active carrier capable of mediating a TH1.fwdarw.TH2 shift, will thus reduce the severity of HVGR.

REFERENCES:
patent: 5356779 (1994-10-01), Mozes et al.
Elias et al Diabetes vol. 44 Sep. 1995 pg. 1132-1138.
Alevy et al Transplantation Mar. 27, 1996 vol. 61, No.:6 pg. 963-967.

Affiliated with

Also associated with

Rating

Method of reducing the severity of host vs graft reaction by dow does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of reducing the severity of host vs graft reaction by dow, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of reducing the severity of host vs graft reaction by dow will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1668020