Method of reducing the chance of attack of cells in a body by th

Details Method of reducing the chance of attack of cells in a body by th Method of reducing the chance of attack of cells in a body by th

1997-10-07

2000-05-02

Saunders, David

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

435 2, 435 724, 435372, 435378, A01N 6300, A01N 6500, A01N 102, G01N 3353

Patent

active

060569514

ABSTRACT:
A method of reducing the chance of disease resulting from mononuclear cells in a body attacking desirable cell antigens in the body, such as antigens expressed by normal body cells or desirable engrafted cells, comprises reducing the number of mononuclear cell in the body that are likely to attack such desirable cell antigens. This is done by obtaining cell derived antigens subject to attack by mononuclear cells in the body and also obtaining mononuclear cells to be placed in the body. The mononuclear cells may be from a donor or may be removed from the subject body. The mononuclear cells are reacted, in vitro, with the cell derived antigens, such as by passing the mononuclear cells over a layer of fibroblast cells from the body expressing the desirable antigens, and recovering the mononuclear cells that do not bind to the antigens. These recovered cells are then infused into the body.

REFERENCES:
patent: 4473647 (1984-09-01), Carpenter et al.
patent: 4500637 (1985-02-01), Neville, Jr. et al.
patent: 4520226 (1985-05-01), Neville, Jr. et al.
patent: 5047401 (1991-09-01), Lipsky et al.
patent: 5178858 (1993-01-01), Reichert et al.
patent: 5593677 (1997-01-01), Reichert et al.
patent: 5595881 (1997-01-01), Kendrick
patent: 5759793 (1998-06-01), Schwartz
Kogler, G., et al., High efficiency of a new immunological magnetic cell sorting method for T cell depletion of human bone marrow. 6:163-168, 1990.
"Prevention of Graft-Versus-Host Disease After Bone Marrow Transplantation", Transplantation Proceedings, vol. 27, No. 5 (Oct.), 1995; pp. 2653-2656, by R. Storb.
"Marrow Transplantation from Unrelated Volunteer Donors" by Claudio Anasetti, M.D., et al., Annu. Rev. Med. 1995, 46 169-79.
Warren, R.P., et al. "Direct and Antibody-Dependent Cell-Mediated Cytotoxicity Against HLA Identical Sibling Lymphocytes", Transplantation, vol. 22, No. 6, pp. 631-635, 1976.

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