Method of reducing the cardiotoxic side effects of glycosidic an

Details Method of reducing the cardiotoxic side effects of glycosidic an Method of reducing the cardiotoxic side effects of glycosidic an

1976-07-12

1977-11-01

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424180, A61K 3748, A61K 3170

Patent

active

040566137

ABSTRACT:
The cardiotoxic effects incident to the use of glycosidic anthracyclinones such as adriamycin, daunomycin, etc., in antitumor therapy, are substantially reduced by administering to a host undergoing such therapy, and effective amount of coenzymes Q, particularly Co-Q.sub.10 (Ubiquinone Q.sub.10).

REFERENCES:
iwamoto et al., Biochem. & Biophy. Res. Commun., vol. 58, No. 3, 1974, pp. 633-638.
Chemical Abstracts 83: 172462g, (Aug. 1975).
Chemical Abstracts 84: 359h, (Aug. 1975).

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