Method of reducing serum levels of lipoprotein(A)

Details Method of reducing serum levels of lipoprotein(A) Method of reducing serum levels of lipoprotein(A)

1991-03-13

1992-05-19

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514444, 514824, A61K 3138

Patent

active

051149630

ABSTRACT:
The present invention is a method for lowering serum levels of Lp(a), thereby reducing the risk of atherosclerotic disease. Specifically, the present invention comprises administering an effective amount of a N,S-diacyl-L-cysteine to a human or animal with elevated serum levels of Lp(a). The N,S-diacyl-L-cysteines comprise a compound selected from the group having the formula: ##STR1## wherein R is selected from the group consisting of hydrogen and an alkyl group containing 1 to 8 carbon atoms and R' is selected from the group consisting of acetyl, benzoly, thenoyl, 2-chromone-carbonyl and succinyl, and pharmaceutically acceptable salts thereof.

REFERENCES:
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patent: 4472424 (1984-09-01), Cavazza
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Description of FLUIMUCIL.TM. granules an N-acetylcysteine composition produced by Laboratory ARSAC, Antibes, France, Vidal, 1987.
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"Academic American Encyclopedia", Prodigy (R) Feb., 1991.
"Principles of Physiology", Ed. R. M. Berne and M. N. Levy pp. 383-385 (1990).
Palma, et al., "N-Acetylcysteine in the Prevention of Cyclophosphamide Induced Haemorrhagic Cystitis", Int. Surg, 71:36-37 (1986).
Ziment, I., "Acetylcysteine: A Drug with an Interesting past and a Fascinating Future", Respir. 50, suppl. 1, pp. 26-30 (1986).
Turner, et al., "The influence of native porcine gastric mucus gel on hydrogen ion diffusion: the effect of potentially ulcerogenic agents", J. Pharm, Pharmacol., 37:776-780 (1985).

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