Method of reducing perivascular lesions using insulin-like growt

Details Method of reducing perivascular lesions using insulin-like growt Method of reducing perivascular lesions using insulin-like growt

1996-08-30

1999-10-12

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 3, 514 21, 530303, A61K 3800

Patent

active

059655313

ABSTRACT:
A disease or disorder associated with myelin injury, such as multiple sclerosis, is treated by administering to a patient in need thereof an effective amount of insulin-like growth factor I (IGF-I). The method reduces blood brain and blood nerve barrier permeability defects. It also decreases the size and number of perivascular lesions (often associated with myelin breakdown) and reduces the formation of sclerotic plaques in the central nervous system. IGF-I administration also reverses the clinical deficits associated with myelin injury, including visual defects, unsteadiness, poor coordination, muscular weakness and paralysis.

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