Perfume compositions – Perfume compositions
Reexamination Certificate
2001-01-05
2004-05-18
Warden, Jill (Department: 1743)
Perfume compositions
Perfume compositions
C424S076400
Reexamination Certificate
active
06737395
ABSTRACT:
This invention relates to perfume components, mixtures thereof and perfume compositions, to personal products and detergent products containing such perfumes, and to a method and the use of such perfumes and products to deliver a deodorant effect.
In particular, it relates to perfume components, mixtures thereof, and perfume compositions for inhibiting the production of odorous metabolites by topically applying to human skin perfumery components capable of inhibiting the production of body malodour caused by micro-organisms comprising corynebacteria, preferably by selectively inhibiting those corynebacteria capable of catabolising fatty acids.
It is well known that freshly secreted sweat is odourless and that body malodour is the result of a biotransformation of the sweat by microorganisms living on the surface of the skin to produce volatile odoriferous compounds.
There are three types of personal product routinely used to combat body malodour: perfumes, antiperspirants and deodorants.
Perfumes may simply mask body malodour. However perfume compositions have been disclosed which exhibit a deodorant action. EP-B-3172, EP-A-5618, U.S. Pat. No. 4,304,4679, U.S. Pat. No. 4,322,308, U.S. Pat. No. 4,278,658, US-A-4,134,838, U.S. Pat. No. 4,288,341 and U.S. Pat. No. 4,289,641 all describe perfume compositions which exhibit a deodorant action when applied to human skin fit or when included in a laundry product used to launder textiles.
Antiperspirants work by blocking the sweat glands thereby reducing perspiration.
Antimicrobial agents used in deodorants are designed to reduce the population of micro-organisms living on the surface of the skin. Typical agents of this nature include ethanol and Triclosan (2,4,4′-trichloro-2′-hydroxy-diphenyl ether) which are well known to exert in antimicrobial effects. The use of common deodorant actives results in a non-selective antimicrobial action exerted upon most of the skin's natural microflora. This is an undesirable side effect of such deodorant formulations.
Many disclosures describe compositions comprising antimicrobials which are designed to eliminate malodour by sub-lethally reducing the microflora population.
WO 95/16429 (Henkel) describes deodorant compositions comprising fat soluble partial esters of hydroxy carboxylic acids.
WO 95/07069, WO 91/11988 and WO 91/05541 (all Gillette) describe deodorant compositions comprising inhibitors of pyridoxal phosphate dependent amino acid lyase.
WO 94/14934 (Unilever) describes a method for reducing the perceptibility of an odoriferous substance using an antibody or antibody fragment. Such antibodies could be used in deodorant compositions.
WO 93/07853 (Monell) describes the use of mimics of the odoriferous compound 3-methyl-2-hexenoic acid to reduce body malodour.
DD 29 39 58 (Medezinische Fakultaet (Charite) der Humboldt Universitaet zu Berlin) describes the use of lipoxygenase Inhibitors to act biochemically to reduce sweat production or to inhibit, to various degrees, the action of skin bacteria or their enzymes on the decomposition of sweat to form unpleasant-smelling substances.
DE 43 43 265 (Henkel) describes deodorant compositions comprising saturated dioic acid (C3-C10) esters. It is claimed that the active inhibits a sweat decomposing esterase and the compositions are said not to disturb the skin's natural microflora.
DE 43 4 254 (Henkel) describes the use of lipid-soluble partial esters of hydroxy carboxylic acids in deodorant compositions.
Some disclosures describe the use of antimicrobial substances which are selective against odour producing bacteria.
WO 90/15077 (Gillette) describes the use of antibodies to a carrier or transport protein of coryneform and staphylococci. It is disclose1 that these bacteria types have an amino acid lyase enzyme which is responsible for the formation of malodour.
DE 43 39 605 (Beiersdorf) describes the use of deodorising mixtures of alpha-omega alkanedioic acids and fatty acid partial glycerides of unbranced fatty acids which may be present in a suitable cosmetic vehicle to combat Gram-positive, particularly coryneform, bacteria.
Woolwax acids have also been disclosed in the following Beiersdorf publications as deodorant actives in combination with:
alpha-omega alkanedioic acids (DE 43 24 219);
partial glycerides of unbranched fatty acids (DE 43 09 372); or
monocatboxylic acids, especially unbranched fatty acids (DE 43 05 889).
Each combination is described as suitable to combat Gram-positive, especially coryneform, bacteria.
DE 4237081 (Beiersdorf) describes deodorant compositions comprising monocarboxylic acid diglycerides and/or triglycerides. The compositions are said to be suitable against Gram-positive, especially coryneform, bacteria.
EP-A-0 697 213 (Beiersdorf) describes the selective reduction of coryneform bacteria using a mixture of:
lauric acid;
one other fatty acid C6-C20 (one of which must be at least C12);
glyceryl monocaprate/glyceryl monocaprylate;
without the use of ethoxylated glyceryl fatty acid esters and propoxylated glyceryl fatty acid esters;
which has a pH of less than B.
WO 94/07837 (Unichema) describes certain novel unsaturated dioic acids having between 8 and 22 carbon atoms. Also described is their potential use to treat malodour.
EP-A-0 750 903 (Cooperatie Cosun UA) discloses deodorant compositions comprising sugar-fatty acid esters. The actives are described as being selective towards odour causing micro-organisms. These odour-causing micro-organisms are said to be the Corynebacterium varieties known as lipophilic diphtheroids such as
Corynebacterium xerosis
and
C. minutissimum.
Coryneform is a designation of a large ill-defined group of bacteria. The diverse genera that have been included with the coryneforms include Actinomyces, Arachnia, Arcanobacterium, Arthrobacter, bacterionema, Bifidobacteriurn, Brevibacterium, Cellulomonas, Corynebacterium. Eyrsipelothrix, Eubacteriumr. Kurthia, Listeria, Mycobacterium, Nocardia, Oerskovia, Propionibacterium, Rhodococcus and Rothia.
It is clear that the majority of previous disclosures in this area have been aimed at antibacterial or bacteriostatic effects towards the whole skin flora or selected species.
Without being bound by theory we believe that the Corynebacterium genus can be subdivided into two subgroups according to ability to catabolise fatty acids. We further believe that one of these subgroups, hereinafter referred to as “Corynebacteria A” which is capable of catabolising fatty acids, contributes strongly to the formation of body malodour, in particular axillary malodour. The other subgroup, hereinafter referred to as “Corynebacteria B”, which catabolises fatty acids much less so or not at all, contributes much less or even not at all to malodour formation. We also believe that it is possible to selectively inhibit the generation of odorous metabolites by Corynebacteria A.
The deodorants available on the market tend to be insufficiently effective and/or substantially reduce the numbers of all bacteria in the microflora indiscriminately. The present invention offers the opportunity to provide deodorant products which for many females will substantially reduce malodour formation while inhibiting only a minor portion of the microflora. For many males malodour formation can be substantially reduced or even largely eliminated by inactivating the Corynebacteria A.
Furthermore, we have found a range of perfume components capable of selectively inactivating Corynebacteria A, while leaving other bacteria, notably Corynebacteria B much less affected or even not notably affected at all. Significant deodorant action can be obtained by the action of these components singly or in combination.
Accordingly, the invention provides a cosmetic method for reducing or preventing body malodour by topically applying to human skin a composition comprising an active agent capable of inactivating body malodour-causing micro-organisms comprising corynebacteria, wherein the agent is a perfume component which is capable of inactivating the corynebacteria capable of cata
Behan John M.
Minhas Tony
Wilson Craig S.
Cole Monique T.
Morgan & Lewis & Bockius, LLP
Quest International B.V.
Warden Jill
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