Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds hormone or other secreted growth regulatory factor,...
Reexamination Certificate
2007-10-23
2007-10-23
Kemmerer, Elizabeth C. (Department: 1649)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Binds hormone or other secreted growth regulatory factor,...
Reexamination Certificate
active
10521167
ABSTRACT:
The present invention relates to methods of treating pain. Monocyte chemoattractant protein-1 (MCP-1) antibodies or binding fragments thereof are used to prevent or reduce behavioral hypersensitivity associated with pain.
REFERENCES:
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Flügel A et al. Neuronal MCP-1 expression in response to remote nerve injury. J. Cerebral Blood Flow Metal. 2001; 21:69-76.
Honore P et al. Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons. Neuroscience, 2000; 98(3):585-598.
Ogata H et al. The role of monocyte chemoattractant protein-1 (MCP-1) in the pathogenesis of collagen-induced arthritis in rats. J. Pathology, 1997; 182: 106-114.
Winkelstein BA et al. Nerve injury proximal or distal to the DRG induces similar spinal glial activation and selective cytokine expression but differential behavioral responses to pharmacologic treatment. J. Comp. Neurol. 2001; 439:127-139.
Abbadie et al., “Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2”, Proc. Natl. Acad. Sci. USA 2003 100(13):7947-7952.
Ballard Kimberly A.
Kemmerer Elizabeth C.
Licata & TYrrell P.C.
Trustees of Dartmouth College
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