Method of reducing neuronal electrical activity with a...

Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...

Reexamination Certificate

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C435S320100, C435S325000, C435S348000, C435S375000

Reexamination Certificate

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10438753

ABSTRACT:
Methods of reducing the excitability of an excitable cell by transforming an excitable cell with a nucleic acid construct encoding an open rectifier K+channel (dORK) (SEQ ID NO:2) or a modified open rectifier K+channel (dORKΔ) (SEQ ID NO:4), and expressing the open rectifier K+channel in the excitable cell, wherein the excitability of the transformed cell is reduced. Also featured are transgenic animals expressing dORK or dORKΔ.

REFERENCES:
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